5-Aza-2'-deoxycytidine
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5-Aza-2'-deoxycytidine 속성
- 녹는점
- ~200 °C (dec.)
- 알파
- D22 +68.5° (30 min) +57.8° (6 hr) (c = 0.5 in water)
- 끓는 점
- 370.01°C (rough estimate)
- 밀도
- 1.3771 (rough estimate)
- 굴절률
- 1.6590 (estimate)
- 저장 조건
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- 용해도
- 에 용해됨 아세트산/물(1:1): 50mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 14.02±0.60(Predicted)
- 색상
- 흰색에서 황백색까지
- Merck
- 14,2853
- BRN
- 617982
- 안정성
- 안정적인. 가볍거나 공기에 민감할 수 있습니다. 강한 산화제와 호환되지 않습니다.
- InChIKey
- XAUDJQYHKZQPEU-KVQBGUIXSA-N
- CAS 데이터베이스
- 2353-33-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,Xi,T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/37/38-68-61 | ||
| 안전지침서 | 26-36-36/37 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | XZ3012000 | ||
| F 고인화성물질 | 10-34 | ||
| HS 번호 | 29349990 | ||
| 독성 | LD50 in mice (mg/kg): 190 i.p. (Momparler, 1985) |
5-Aza-2'-deoxycytidine C화학적 특성, 용도, 생산
개요
Decitabine, 5-aza-2’-deoxycytidine, has been launched for the treatment of myelodysplastic syndromes (MDS). MDS are a set of hematologic disorders affecting the bone marrow that result in ineffective formation and development of blood cells. Furthermore, patients with MDS have a high risk of progressing to acute myeloid leukemia (AML). Traditional treatments include blood transfusions, hematopoietic growth factors, and prophylactic antibiotics, but these measures merely improve the quality of life with questionable effects on disease modification. While stem-cell transplantation is an aggressive, potentially curative approach, the advanced age or the other complicating health issues of most patients preclude them from considering this option. Recent advances in the underlying etiology of MDS, however, have led to the development of a new class of compounds known as ‘‘demethylating agents’’. Decitabine follows the successful introduction of the first DNA methyltransferase inhibitor azacitidine.화학적 성질
white crystalline powder용도
Used as cancer treatment, in particular to inhibit the growth of pancreatic endocrine tumor cell lines.일반 설명
Fine white crystalline powder. Used as a drug.공기와 물의 반응
Probably light and air sensitive. Water soluble. Decomposes in aqueous solution at a rate that depends on pH: at pH 7 the drug is more stable than at pH 9, but is less stable than at pH 6. At pH 7 and 99°F, approximately 7% conversion occurs in 1 hour .반응 프로필
5-Aza-2'-deoxycytidine is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.화재위험
Flash point data for 5-Aza-2'-deoxycytidine are not available. 5-Aza-2'-deoxycytidine is probably combustible.생물학적 활성
Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.Safety Profile
Poison by intravenous route.Human mutation data reported. When heated todecomposition it emits toxic fumes of NOx.5-Aza-2'-deoxycytidine 준비 용품 및 원자재
원자재
N-(트리메틸실릴)-4-[(트리메틸실릴)옥시]-2-아민-1,3,5-트리아진
3',5'-디-op-클로로벤조일-2-데옥시-5-아자시토신
D-erythro-Pentofuranosyl chloride, 2-deoxy-
1,1'-Bi-2-naphthol
트리에틸아민
N,N-다이메틸폼아마이드
질산코발트
준비 용품
5-Aza-2'-deoxycytidine 공급 업체
글로벌( 721)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Beijing Ribio Biotech Co.,Ltd | 010-62664360 +8613328773880 |
wucy@ribio.com.cn | China | 117 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 |
sales@hbmojin.com | China | 12248 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 |
mina@chuanghaibio.com | China | 18126 | 58 |
| Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 295 | 58 |
| Wuhan JiyunZen Tech Co., Ltd. | +86-18062099985 |
Amyjiyunzen@yeah.net | China | 663 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 |
sales@capot.com | China | 29734 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21620 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| Lianyungang happen teng technology co., LTD | 15950718863 |
wang666xt@163.com | CHINA | 295 | 58 |