Losartan
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Losartan 속성
- 녹는점
- 183-184 C
- 끓는 점
- 682.0±65.0 °C(Predicted)
- 밀도
- 1.35±0.1 g/cm3(Predicted)
- 증기압
- 0.002Pa at 20℃
- 저장 조건
- under inert gas (nitrogen or Argon) at 2-8°C
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 5-6(at 25℃)
- 색상
- 흰색에서 황백색까지
- 수용성
- 4.8mg/L at 20℃
- LogP
- 1.1 at 20℃
- CAS 데이터베이스
- 114798-26-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-36 | ||
| 유해 물질 데이터 | 114798-26-4(Hazardous Substances Data) |
| 그림문자(GHS): |
 
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| 신호 어: | Danger | |||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Losartan C화학적 특성, 용도, 생산
용도
Losartan is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.정의
ChEBI: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position일반 설명
Losartan, 2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5-yl-phenyl)benzyl]imidazole-5-methanol monopotassiumsalt (Cozarr), was the first nonpeptide imidazole to beintroduced as an orally active angiotensin II antagonist withhigh specificity for AT1. When administered to patients, itundergoes extensive first-pass metabolism, with the 5-methanol being oxidized to a carboxylic acid. This metabolismis mediated by CYP 2C9 and 3A4 isozymes. The 5-methanol metabolite is approximately 15 times more potentthan the parent hydroxyl compound. Because the parent hydroxylcompound has affinity for the AT1 receptor, strictlyspeaking, it is not a prodrug.Losartan 준비 용품 및 원자재
원자재
1-메틸이미다졸
소디움 아지이드
Losartan carboxylic acid
Methanol solution of sodium methoxide
2-n-Butyl-4-Chloro-5-Hydroxymethyl Imidazole
메틸4'-메틸비페닐-2-카르복실레이트
염화 티오닐
암모니아수
수산화칼륨
준비 용품
Losartan 공급 업체
글로벌( 308)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 |
Sibel@chuanghaibio.com | China | 8772 | 58 |
| Sichuan Zhuoyu Yantang Technology Co., Ltd. | +8613288715578 |
sales@sichuanzyyt.com | China | 12246 | 58 |
| Sinoway Industrial co., ltd. | +86-0592-5800732 +86-13806035118 |
xie@china-sinoway.com | China | 1113 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 |
sales@capot.com | China | 29734 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21620 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29852 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2930 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10405 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49975 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 +86-17392581500 |
1015@dideu.com | China | 3965 | 58 |