2-피페리디논,3,3-디클로로-1-(4-니트로페닐)-
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2-피페리디논,3,3-디클로로-1-(4-니트로페닐)- 속성
- 끓는 점
- 520.2±50.0 °C(Predicted)
- 밀도
- 1.50
- 저장 조건
- 2-8°C
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨, 초음파처리)
- 산도 계수 (pKa)
- -7.38±0.40(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 밝은 노란색에서 노란색까지
- InChI
- InChI=1S/C11H10Cl2N2O3/c12-11(13)6-1-7-14(10(11)16)8-2-4-9(5-3-8)15(17)18/h2-5H,1,6-7H2
- InChIKey
- KKVYXBZVPRSWHE-UHFFFAOYSA-N
- SMILES
- N1(C2=CC=C([N+]([O-])=O)C=C2)CCCC(Cl)(Cl)C1=O
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 그림문자(GHS): |
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| 유해·위험 문구: |
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| 예방조치문구: |
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2-피페리디논,3,3-디클로로-1-(4-니트로페닐)- C화학적 특성, 용도, 생산
개요
3, 3-dichloro-1 -(4-nitrophenyl) -2-piperidinone is an important pharmaceutical intermediate, as it can be used to prepare apixaban derivatives. Apixaban is a small molecular selective FXa inhibitor of pyrazole derivatives. Similar to Rivaroxaban, apixaban has two binding sites to Factor Xa, where 4-methoxyphenyl in the apixaban structure partially binds the S1 pocket of Factor Xa and aryllactam partially binds the S4 pocket of Factor Xa.2-피페리디논,3,3-디클로로-1-(4-니트로페닐)- 준비 용품 및 원자재
원자재
준비 용품
2-피페리디논,3,3-디클로로-1-(4-니트로페닐)- 공급 업체
글로벌( 138)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21620 | 55 |
| Jinan Chenghui-Shuangda Chemical Co.,Ltd | +86-531-58897082 |
ericqiao@jnchsd.com | CHINA | 158 | 58 |
| Jinan Jianfeng Chemical Co., Ltd | +86-0531-88110457 +86-15562555968 |
info@pharmachemm.com | China | 312 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14332 | 58 |
| Synbest Biotech(Hangzhou) Co., Ltd | 86-571-88737065 |
sales@synbestech.com | CHINA | 170 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29800 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 |
contact@trustwe.com | China | 5744 | 58 |
| Wuhan Boye Science And Technology Development Co., Ltd. | 27-81625225 +8615387090420 |
sumihu@boyechemicals.com | CHINA | 215 | 58 |
2-피페리디논,3,3-디클로로-1-(4-니트로페닐)- 관련 검색:
(4,4'-디도데실-2,2'-비티오펜-5,5'-디일)비스(트리메틸스탄앤) 아픽사반-13C-D3 에틸(2Z)-클로로[(4-메톡시페닐)히드라조노]에타노에이트 아픽사반IMpurity6 아세트산,2-클로로-2-[2-(4-메톡시페닐)히드라지닐리덴],에틸에스테르 에틸(2E)-클로로[(4-클로로페닐)하이드라조노]아세트산
1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide
Apixaban IMpurity 3
1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid
Apixaban IMpurity(
Apixaban
1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide
1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
Apixaban IMpurity(BMS-778960-01)
Apixaban IMpurity 5 (BMS-591329-01)
Apixaban Impurity 16