Adriamycin manufacturers and suppliers

Adriamycin suppliers

Properties

Melting point:: 205°C

Boiling point:: 617.77°C (rough estimate)

Density: 1.3783 (rough estimate)

refractive index: 1.6400 (estimate)

storage temp.: Keep in dark place,Sealed in dry,2-8°C

solubility: ≥27.2 mg/mL in DMSO; insoluble in EtOH; ≥24.8 mg/mL in H2O with ultrasonic

pka: pKa 8.2 (Uncertain)

form: solid

Water Solubility: Soluble

InChIKey: AOJJSUZBOXZQNB-XFGIOHMQNA-N

SMILES: OC1C2C(C3=CC=CC(OC)=C3C(=O)C=2C(O)=C2[C@H](C[C@](O)(C(=O)CO)CC=12)O[C@]1([H])O[C@@H](C)[C@@H](O)[C@@H](N)C1)=O |&1:18,20,29,32,34,36,r|

CAS DataBase Reference: 23214-92-8

IARC: 2A (Vol. 10, Sup 7) 1987

EPA Substance Registry System: Doxorubicin (23214-92-8)

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Danger

Hazard statements: H302-H315-H319-H335-H350-H362

Precautionary statements: P260-P263-P280

HS Code: 2941900000

Hazardous Substances Data: 23214-92-8(Hazardous Substances Data)

Toxicity: An anthracycline cytotoxic antineoplastic that is produced by Streptomyces peucetius. The LD50 in mice is 9.4 mg/kg, i.v. It is a carcinogen that inhibits DNA and RNA synthesis by intercalating in double-stranded DNA with the amino sugar in the minor groove and the 90-OH group of the anthracycline ring hydrogen-bonded to the adjacent guanine. It also alters membrane fluidity and ion transport, and generates free radicals through a cytochrome P450-mediated reductive process. In humans, it causes alopecia, stomatitis, nausea, vomiting, diarrhea, cardiotoxicity (manifested by tachycardia), and potentially fatal congestive heart failure.

Use

Doxorubicin (adriamycin) is the most extensively studied of a family of highly fluorescent anthracycline antibiotics produced by several Streptomyces species, first reported in 1967 and later approved for human therapeutic use as an antitumour agent for the treatment of a wide range of cancers. Doxorubicin also exhibits anti-HIV and antibacterial activity. The mode of action of doxorubicin is thought to be due to intercalation of DNA and inhibition of nucleic acid synthesis.Clinically it is applied for the treatment of acute and chronic lymphocytic leukemia and solid tumor leukemia, lymphoma, breast cancer, ovarian cancer, soft tissue sarcoma, osteogenic sarcoma, rhabdomyosarcoma, ewings sarcoma, nephroblastoma, neuroblastoma, gastric cancer, pancreatic cancer, liver cancer, prostate cancer, head and neck squamous cell carcinoma, testicular cancer, lung cancer, bladder cancer, medullary thyroid carcinoma and sarcoma.

You can find Adriamycin suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.