Azasetron hydrochloride manufacturers and suppliers

Azasetron hydrochloride suppliers

Properties

Melting point:: 281° (dec); mp 305° (dec) (Kawakita)

storage temp.: Sealed in dry,Room Temperature

solubility: Methanol (Slightly), Water (Slightly)

form: White solid.

color: White

Water Solubility: H2O: 2mg/mL, clear

InChI: InChI=1/C17H20ClN3O3.ClH/c1-20-14-7-11(18)6-12(16(14)24-9-15(20)22)17(23)19-13-8-21-4-2-10(13)3-5-21;/h6-7,10,13H,2-5,8-9H2,1H3,(H,19,23);1H

InChIKey: DBMKBKPJYAHLQP-UHFFFAOYNA-N

SMILES: C12OCC(=O)N(C)C=1C=C(Cl)C=C2C(=O)NC1CN2CC[C@]1([H])CC2.Cl |&1:21,r|

CAS DataBase Reference: 123040-16-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H361

Precautionary statements: P201-P202-P281-P308+P313-P405-P501

WGK Germany: WGK 3

Storage Class: 11 - Combustible Solids

Toxicity: LD50 in male, female rats (mg/kg): 135, 132 i.v. (Takagi)

Use

Nazasetron (azasetron) hydrochloride is the fourth in the class of highly potent 5- HT3 receptor antagonists to reach the market for prophylaxis of severe nausea and vomiting induced by cytotoxic chemotherapy and by total body X-radiation. In a study with 146 cancer patients suffering from emesis induced by cisplatin, nazasetron was reported to be markedly effective in 72% of subjects. Nazasetron is devoid of dopamine D2 receptor blocking activity and therefore is free of the extrapyrimidal side effects associated with other commonly used antiemetics such as metoclopramide and domperidone. Nazasetron has been reported to be potentially useful for the treatment of gastrointestinal motility dysfunction, such as gastric stasis, vomiting and irritable bowel syndrome.

You can find Azasetron hydrochloride suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.