Alectinib manufacturers and suppliers

Alectinib suppliers

Properties

Melting point:: 274-276°C

Boiling point:: 722.5±60.0 °C(Predicted)

Density: 1.28

storage temp.: -20°

solubility: Soluble in DMSO (up to 5 mg/ml with warming).

pka: 13.70±0.40(Predicted)

form: solid

color: White

Stability:: Stable for 1 year from date of purchase as supplied. Solutions are not stable and should be prepared fresh daily.

InChIKey: KDGFLJKFZUIJMX-UHFFFAOYSA-N

SMILES: N1C2=C(C=CC(C#N)=C2)C2=C1C(C)(C)C1=CC(N3CCC(N4CCOCC4)CC3)=C(CC)C=C1C2=O

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H361-H341-H373

Precautionary statements: P201-P202-P281-P308+P313-P405-P501-P201-P202-P281-P308+P313-P405-P501-P260-P314-P501

HS Code: 2934999090

Use

Alectinib (Alecensa(R), Roche) was approved first in Japan in 2014 and then by US FDA in 2015 as a second-generation ALK inhibitor for NSCLC treatment on patients who have progressed or do not tolerate crizotinib. Developed through a structure-based drug design approach, alectinib is a benzocarbazolone derivative that has shown potent inhibitory activity against ALK (IC50 value of 1.9 nM) and gatekeeper mutant L1196M ALK (IC50 value of 1.6 nM). Alectinib is effective with crizotinib-resistant ALK mutations on L1196M, F1174L, R1275Q, and C1156Y. In addition, an array of small-molecule inhibitors are currently being evaluated by several clinical trials for ALK-driven tumors.

You can find Alectinib suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.