APHIDICOLIN manufacturers and suppliers

APHIDICOLIN suppliers

Properties

Melting point:: 218-220°C

alpha: D27 +12° (c = 1 in methanol)

Boiling point:: 394.61°C (rough estimate)

Density: 1.0057 (rough estimate)

vapor pressure: 0.55 hPa ( 20 °C)

refractive index: 1.4434 (estimate)

Flash point:: 87℃

storage temp.: 2-8°C

solubility: ethanol: soluble1mg/mL (stable at least a week at 4°C.)

form: White solid

pka: 14.24±0.70(Predicted)

color: colorless

optical activity: [α]27/D +12°, c = 1 in methanol(lit.)

biological source: Nigrospora sphaerica

Water Solubility: Soluble in DMSO or methanol. Insoluble in water. Store solutions at -20°

Merck: 13,734

BRN: 4689958

Stability:: Stable for 2 years from date of purchase from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

InChI: 1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1

InChIKey: NOFOAYPPHIUXJR-APNQCZIXSA-N

SMILES: O[C@]1([C@H]2C[C@@]3([C@@]4([C@H]([C@@]([C@@H](CC4)O)(CO)C)CC[C@H]3C2)C)CC1)CO

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P271-P280

Safety Statements: 22-24

RIDADR: NA 1993 / PGIII

WGK Germany: 3

RTECS: PB9185000

F: 10-21

HS Code: 29419090

Storage Class: 10 - Combustible liquids

Use

Aphidicolin is a tetracyclic diterpene antibiotic isolated from fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties, blocking the cell cycle at early S-phase. This property has been used to synchronise cell division and is useful as a tool in cell differentiation research. Aphidicolin is a reversible inhibitor of DNA replication by inhibiting selected DNA polymerases. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumor agents, vincristine and doxorubicin.

You can find APHIDICOLIN suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.