DBeQ manufacturers and suppliers

DBeQ suppliers

DBeQ

CAS:: 177355-84-9

MF:: C22H20N4

MW:: 340.42

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Properties

Melting point:: 149 °C

Boiling point:: 573.1±52.0 °C(Predicted)

Density: 1.259±0.06 g/cm3(Predicted)

storage temp.: room temp

solubility: DMSO: ≥20mg/mL

form: powder

pka: 7.78±0.30(Predicted)

color: white to beige

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

InChI: 1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)

InChIKey: QAIMUUJJAJBPCL-UHFFFAOYSA-N

SMILES: C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4

CAS DataBase Reference: 177355-84-9

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H319

Precautionary statements: P305+P351+P338

Hazard Codes: Xn

Risk Statements: 22-36

Safety Statements: 26

WGK Germany: 3

HS Code: 2933.59.8000

Storage Class: 11 - Combustible Solids

Use

The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM. At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.[Cayman Chemical]

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