Deferiprone manufacturers and suppliers

Deferiprone suppliers

Properties

Melting point:: 272-275 °C (lit.)

Boiling point:: 255.1°C (rough estimate)

Density: 1.1997 (rough estimate)

refractive index: 1.4800 (estimate)

storage temp.: 2-8°C

solubility: Soluble in Water (up to 5 mg/ml with warming).

form: Crystalline Powder or Needles

pka: pKa1 3.3, pKa2 9.7(at 25℃)

color: White to off-white

Water Solubility: Soluble in hot water

Merck: 14,2859

Stability:: Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily.

InChI: InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3

InChIKey: TZXKOCQBRNJULO-UHFFFAOYSA-N

SMILES: C1(C)N(C)C=CC(=O)C=1O

CAS DataBase Reference: 30652-11-0(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P301+P312+P330

PPE: dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes: Xn

Risk Statements: 22-36/37/38

Safety Statements: 26-36-37/39

WGK Germany: 3

RTECS: UU7785940

HS Code: 29333990

Storage Class: 11 - Combustible Solids

Hazard Classifications: Acute Tox. 4 Oral

Hazardous Substances Data: 30652-11-0(Hazardous Substances Data)

Toxicity: LD50 i.p. in rats, mice: 650 mg/kg, 0.8-1.0 g/kg; i.g. in rats: 2.0-3.0 g/kg (Kontoghiorghes, 1995)

Use

Deferiprone, the first oral iron chelator, was marketed in India for the management of thalassaemia. Patients with thalassaemia, a blood related genetic disorder, require life time transfusion which causes excessive deposition of iron in liver and spleen, subsequent damage to organs and eventually death unless iron is removed by a chelator. Deferiprone is a potent iron chelator that mobilizes excessive iron from iron storage proteins ferritin and hemosiderin, from iron saturated transferrin and lactoferrin, but not from hemoglobin. The deferiprone-iron complex is excreted in urine and bile. Deferiprone was reportedly well accepted by patients and no hematological toxicity was observed. Deferiprone has also been demonstrated as an effective and safe chelator in the mobilization of aluminum.

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