Dynasore manufacturers and suppliers

Dynasore suppliers

Dynasore

CAS:: 304448-55-3

MF:: C18H14N2O4

MW:: 322.31

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Properties

Melting point:: >224°C (dec.)

Density: 1.36±0.1 g/cm3(Predicted)

storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility: Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 1 mg/ml).

form: Off-white solid.

pka: 8.49±0.35(Predicted)

color: Beige

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

InChI: 1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+

InChIKey: SYNDQCRDGGCQRZ-VXLYETTFSA-N

SMILES: N(\N=C\c3cc(c(cc3)O)O)C(=O)c1cc2c(cc1O)cccc2

CAS DataBase Reference: 304448-55-3

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319

Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Hazard Codes: N

Risk Statements: 50

Safety Statements: 22-24/25-61

RIDADR: UN 3077 9/PG 3

WGK Germany: WGK 3

HS Code: 2928.00.2500

Storage Class: 11 - Combustible Solids

Use

Dynasore is a cell-permeable, reversible inhibitor of dynamin 1, dynamin 2, and mitochondrial dynamin, Drp1 GTPase activity (IC50 = 15 μM). Through this action, dynasore inhibits clathrin-dependent vesicle formation and endocytosis, which is necessary for internalization of certain parasites and viruses, as well as particles and receptor ligands. In some cases, dynasore can also augment the release of neurotransmitters and secreted cytokines.[Cayman Chemical]

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