Naproxen manufacturers and suppliers

Naproxen suppliers

Properties

Melting point:: 152-154 °C (lit.)

alpha: D +66° (in chloroform)

Boiling point:: 332.25°C (rough estimate)

Density: 1.1450 (rough estimate)

refractive index: 67.5 ° (C=1, CHCl3)

Flash point:: 9℃

storage temp.: 2-8°C

solubility: Practically insoluble in water, soluble in ethanol (96 per cent) and in methanol.

pka: pKa 4.28± 0.02(H2O,t =25,I=0.01) (Uncertain)

form: powder

color: White to Almost white

optical activity: [α]25/D +66°, c = 1 in chloroform

Water Solubility: Insoluble in water.

Merck: 14,6417

BRN: 3591067

BCS Class: 2

Major Application: clinical
environmental
forensics and toxicology
pharmaceutical (small molecule)

Cosmetics Ingredients Functions: SKIN CONDITIONING

InChI: 1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1

InChIKey: CMWTZPSULFXXJA-VIFPVBQESA-N

SMILES: COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O

LogP: 3.18

CAS DataBase Reference: 22204-53-1(CAS DataBase Reference)

NIST Chemistry Reference: Naproxen(22204-53-1)

EPA Substance Registry System: 2-Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, (.alpha.S)- (22204-53-1)

Safety Information

Symbol(GHS): GHS07,GHS08,GHS09

Signal word: Warning

Hazard statements: H302-H315-H319-H335-H361fd-H411

Precautionary statements: P202-P273-P301+P312-P302+P352-P305+P351+P338-P308+P313

target organs: Respiratory system

PPE: dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes: Xn,T,F

Risk Statements: 22-39/23/24/25-23/24/25-11-36/37/38

Safety Statements: 36/37-45-16-7-26

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: UF5275000

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29189900

Storage Class: 11 - Combustible Solids

Hazard Classifications: Acute Tox. 4 Oral
Aquatic Chronic 2
Eye Irrit. 2
Repr. 2
Skin Irrit. 2
STOT SE 3

Hazardous Substances Data: 22204-53-1(Hazardous Substances Data)

Toxicity: LD50 in mice (mg/kg): 435 i.v.; 1234 orally; in rats (mg/kg): 575 i.p.; 534 orally (Roszkowski)

Limited Quantities: 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

Use

Naproxen (Naprosyn, Anaprox), marketed as the (S)-enantiomer,is well absorbed after oral administration, givingpeak plasma levels in 2 to 4 hours and a half-life of 13 hours.Naproxen is highly protein bound and displaces most protein-bound drugs. It is recommended for use in RA, OA, acute gouty inflammation, and in primary dysmenorrhea. Itshows good analgesic activity (i.e., 400 mg is comparable to75–150 mg of oral meperidine and superior to 65 mg ofpropoxyphene and 325 mg of aspirin plus 30 mg of codeine).It is also available OTC as 200-mg tablets (Aleve).

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