Norepinephrine manufacturers and suppliers

Norepinephrine suppliers

Properties

Melting point:: 220-230°C

alpha: D25 -37.3° (c = 5 in water with 1 equiv HCl)

Boiling point:: 298.46°C (rough estimate)

Density: 1.2435 (rough estimate)

refractive index: 1.5100 (estimate)

storage temp.: 2-8°C

solubility: Aqueous Acid (Slightly), DMSO (Slightly)

form: crystalline

pka: 8.64(at 25℃)

color: off-white to tan

optical activity: D +37.426 (c 5, H2O+HCl)L -37.1325 (c 5, H2O+HCl)

Water Solubility: Soluble in alkali and dilute hydrochloric acid. Slightly soluble in water, ethanol and diethyl ether.

Sensitive: Air & Light Sensitive

Merck: 14,6695

BRN: 4231961

Stability:: Stable, but may be light-sensitive. Incompatible with acids, bases, oxidizing agents. Store at -20℃.

InChI: 1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1

InChIKey: SFLSHLFXELFNJZ-QMMMGPOBSA-N

SMILES: NC[C@H](O)c1ccc(O)c(O)c1

CAS DataBase Reference: 51-41-2(CAS DataBase Reference)

EPA Substance Registry System: Norepinephrine (51-41-2)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H300+H310+H330

Precautionary statements: P260-P262-P264-P280-P302+P352+P310-P304+P340+P310

PPE: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes: T+,C,F

Risk Statements: 26/27/28-34-11-28

Safety Statements: 28-36/37-45-36/37/39-26-16-20

RIDADR: UN 2811 6.1/PG 2

WGK Germany: 3

RTECS: DN5950000

F: 8-10-23

HazardClass: 6.1

PackingGroup: II

HS Code: 29225090

Storage Class: 6.1B - Non-combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications: Acute Tox. 1 Inhalation
Acute Tox. 2 Dermal
Acute Tox. 2 Oral

Hazardous Substances Data: 51-41-2(Hazardous Substances Data)

Toxicity: dni-hmn:oth 5800 nmol/L CNREA8 40,1414,80

Use

Norepinephrine (NE, Levophed) differs from DA onlyby addition of a 1-OH substituent (β-OH-DA) and from Eonly by lacking the N-methyl group. Like DA, it is polar andrapidly metabolized by both COMT and MAO, resulting inpoor oral bioavailability and short DOA (1 or 2 minutes evenwhen given intravenously). It is a stimulant of α1-, α2-, andβ1-adrenoceptors (notice that lacking the N-methyl group resultsin lacking β2- and β3-activity). It is used to counteractvarious hypotensive crises, because its α-activity raisesblood pressure and as an adjunct treatment in cardiac arrestbecause its β-activity stimulates the heart. It has limitedclinical application caused by the nonselective nature of itsactivities.

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