Prostaglandin E1 manufacturers and suppliers

Prostaglandin E1 suppliers

Properties

Melting point:: 115-116 °C

alpha: -64 º (c=1.0, C2H5OH)

Boiling point:: 407.69°C (rough estimate)

Density: 1.0458 (rough estimate)

refractive index: 1.6120 (estimate)

storage temp.: -20°C

solubility: ethanol: 1 mg/mL

pka: pKa 4.85± 0.07(H2O,t=25±0.1,I=0.1(NaCl)) (Uncertain)

form: powder

color: White to off-white

biological source: synthetic (organic)

Water Solubility: insoluble

Merck: 13,7968

BRN: 5294062

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

InChI: 1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1

InChIKey: GMVPRGQOIOIIMI-DWKJAMRDSA-N

SMILES: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301

Precautionary statements: P301+P310+P330

Hazard Codes: Xn,Xi

Risk Statements: 22-36/37/38-61

Safety Statements: 36-26

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: GY4569800

F: 8-10

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29375000

Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications: Acute Tox. 3 Oral

Use

Prostaglandin E1 (Prostaglandin E1), also known as alprostadil. Prostaglandin E1 is widely present in the body of biologically active substances, as one of the prostaglandin family, it is a recognized endogenous physiologically active substances. Prostaglandin E1 acts directly on vascular smooth muscle, dilates blood vessels, increases blood flow, improves microcirculation perfusion; and inhibits platelet aggregation and thromboxane A2 production, inhibits atherosclerosis, lipid plaque and immune complex formation; it also owns following effects: the expansion of the periphery small blood vessels and coronary arteries, reduction of peripheral vascular resistance and blood pressure, protection platelet membrane against thrombosis; protection the ischemic myocardium, reducing myocardial infarct size; anti-heart failure; renal vascular dilation, increased renal blood flow, removal of non-protein nitrogen, regulating sodium and water balance, with a diuretic and renal-protecting function. t1/2 is 5~10min. 68% is excreted by renal after hepatic metabolism . Clinical usage includes angina pectoris, myocardial infarction, pulmonary hypertension, chronic arterial occlusion. The above information is edited by the chemicalbook of Tian Ye.

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