Sumatriptan manufacturers and suppliers

Sumatriptan suppliers

Properties

Melting point:: 169-171°C

Boiling point:: 497.7±55.0 °C(Predicted)

Density: 1.1778 (rough estimate)

refractive index: 1.6740 (estimate)

storage temp.: Refrigerator

solubility: DMSO (Slightly), Methanol (Slightly)

pka: pKa 9.5 (Uncertain)

form: Solid

color: Off-White to Pale Yellow

Water Solubility: 21.4 mg/mL

Henry's Law Constant: 2.2×10⁸ mol/(m³Pa) at 25℃, HSDB (2015)

Major Application: pharmaceutical

InChI: InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3

InChIKey: KQKPFRSPSRPDEB-UHFFFAOYSA-N

SMILES: N1C2=C(C=C(CS(NC)(=O)=O)C=C2)C(CCN(C)C)=C1

CAS DataBase Reference: 103628-46-2(CAS DataBase Reference)

NIST Chemistry Reference: Sumatriptan(103628-46-2)

EPA Substance Registry System: 1H-Indole-5-methanesulfonamide, 3-[2-(dimethylamino)ethyl]-N-methyl- (103628-46-2)

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H361d-H412

Precautionary statements: P202-P273-P280-P308+P313-P405-P501

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26

WGK Germany: 3

HS Code: 2935904000

Storage Class: 13 - Non Combustible Solids

Hazard Classifications: Aquatic Chronic 3
Repr. 2

Hazardous Substances Data: 103628-46-2(Hazardous Substances Data)

Use

Sumatriptan was the first triptan approved (1991) for theacute treatment of migraine headaches. It has the lowestoral bioavailability among all triptans because of its lowlipophilicity. The availability of many different dosageforms (i.e., an oral tablet, a SC injection, a nasal spray formulation,and a suppository) allows the flexibility of tailoringtherapy to the needs of the individual patients, thusmaking sumatriptans a very useful drug for an acute treatmentof migraine headaches. It also has a very fastonset of action via SC injection or nasal spray administration.However, sumatriptan is contraindicated withmonoamine oxidase inhibitors because it is primarily degradedby hepatic MAO-A. Thus, it may require frequentdosing as a result of its short duration of action to preventmigraine recurrence.

You can find Sumatriptan suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.