Teniposide manufacturers and suppliers

Teniposide suppliers

Properties

Melting point:: 244-247°C

alpha: D20 -107° (9:1 chloroform/methanol)

Boiling point:: 650.86°C (rough estimate)

Density: 1.2568 (rough estimate)

refractive index: 1.5530 (estimate)

storage temp.: -20°C

solubility: DMSO: soluble10mg/mL, clear

pka: 10.13(at 25℃)

form: powder

color: white to beige

optical activity: [α]/D -100 to -115°, c = 1 in chloroform/methanol (9:1)

λmax: 283nm(MeOH)(lit.)

Merck: 14,9145

Stability:: Hygroscopic

InChIKey: NRUKOCRGYNPUPR-QBPJDGROSA-N

SMILES: [s]1c(ccc1)[C@H]2O[C@@H]3[C@H](O[C@H]([C@@H]([C@H]3O)O)O[C@H]4[C@@H]5[C@@H]([C@@H](c7c4cc8c(c7)OCO8)c6cc(c(c(c6)OC)O)OC)C(=O)OC5)CO2

CAS DataBase Reference: 29767-20-2(CAS DataBase Reference)

IARC: 2A (Vol. 76) 2000

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H341-H412

Precautionary statements: P202-P273-P280-P308+P313-P405-P501

Hazard Codes: Xi,T

Risk Statements: 36/37/38-45

Safety Statements: 26-36-45-53

RIDADR: UN 2811 6.1 / PGIII

WGK Germany: 3

RTECS: KC0180000

HS Code: 29349990

Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications: Carc. 1B

Hazardous Substances Data: 29767-20-2(Hazardous Substances Data)

Toxicity: LD50 intraperitoneal in mouse: 29570ug/kg

Use

Teniposide is available in 50-mg ampules with Cremophor ELfor IV administration in the treatment of acute lymphoblasticleukemia (ALL). The agent is more potent as an inhibitor oftopoisomerase II. The pharmacokinetics of teniposide issimilar to that of etoposide; however, the more lipophilic teniposideis more highly protein bound (99%) and less isexcreted unchanged in the urine (10%–20%). There is alsogreater overall metabolism of teniposide; however, CYP3A4-mediated conversion to the active catechol is slower comparedwith etoposide. Elimination occurs primarily in the urine witha terminal elimination half-life of 5 hours.

You can find Teniposide suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.