THIOLUTIN manufacturers and suppliers

Thiolutin suppliers

Properties

Melting point:: 273-276℃

Boiling point:: 200°C (rough estimate)

Density: 1.4614 (rough estimate)

refractive index: 1.5690 (estimate)

storage temp.: −20°C

solubility: DMSO: 5 mg/mL

pka: 10.54±0.20(Predicted)

form: Yellow crystalline solid.

color: Brilliant-yellow needles from 1-butanol

biological source: Streptomyces luteosporeus

Stability:: Stable for 3 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

InChI: 1S/C9H10N2O2S2/c1-3-6(12)10-7-8-5(4-14-15-8)11(2)9(7)13/h4H,3H2,1-2H3,(H,10,12)

InChIKey: UGZYFXMSMFMTSM-UHFFFAOYSA-N

SMILES: CCC(=O)NC1=C2SSC=C2N(C)C1=O

EPA Substance Registry System: Thiolutin (87-11-6)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H300

Precautionary statements: P264-P270-P301+P310-P405-P501

PPE: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes: T+,T

Risk Statements: 28

Safety Statements: 45

RIDADR: UN 2811 6.1/PG 2

WGK Germany: 3

RTECS: JP1355000

HS Code: 29419090

Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications: Acute Tox. 2 Oral

Toxicity: LD50 in mice (mg/kg): 25 s.c.; 25 orally (Seneca)

Use

Thiolutin is an antibiotic first described by Tanner and co-workers in 1950. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumor activity. Thiolutin is a potent inhibitor of bacterial and yeast RNA polymerases, and also inhibits mannan and glucan formation in fungi. Thiolutin suppresses tumor cell-induced angiogenesis in vivo.

You can find Thiolutin suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.