Tranilast suppliers
Tranilast
- CAS:
- 53902-12-8
- MF:
- C18H17NO5
- MW:
- 327.33
Certification
- GMP
Suppliers by country/region
Company Type
Properties
- Melting point:
- 166.2-168.2 °C (lit.)
- Boiling point:
- 465.23°C (rough estimate)
- Density
- 1.3185 (rough estimate)
- refractive index
- 1.5100 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO: 18 mg/mL
- form
- powder
- pka
- 3.47±0.36(Predicted)
- color
- white to beige
- Merck
- 14,9570
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChI
- 1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
- InChIKey
- NZHGWWWHIYHZNX-CSKARUKUSA-N
- SMILES
- COc1ccc(\C=C\C(=O)Nc2ccccc2C(O)=O)cc1OC
- CAS DataBase Reference
- 53902-12-8(CAS DataBase Reference)
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312-P501
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- DG8731000
- HS Code
- 2924.29.6250
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
- Toxicity
- LD50 in male, female mice, male, female rats (mg/kg): 780, 680, 1600, 1100 orally; 410, 385, 405, 395 i.p.; 2630, 2820, 3630, 3060 s.c. (Nakazawa, p 385)
Use
Tranilast is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells. Tranilast suppresses production of prostaglandin D2 (IC50 = 0.1 mM), prostaglandin E2 (IC50 = ~1-20 μM), thromboxane B2 (IC50 = ~10-50 μM), TGF-β1 (IC50 = ~100-200 μM), and interleukin-8 (IC50 = ~100 μM) in in vitro models as well as attenuates of the proinflammatory activity of human monocytes. While originally marketed as an antiallergenic drug, the efficacy of tranilast in preventing restenosis after percutaneous coronary intervention has been tested in a large-scale clinical trial. Additionally, tranilast inhibits VEGF-induced angiogenetic activities (i.e., proliferation, migration and tube formation of vascular endothelial cells) with IC50 values of 22, 18 and 193 μM, which may prove therapeutic for various retinal diseases.[Cayman Chemical]
186 supplier list of "Tranilast"
- Product Name:Tranilast
- Products Intro:CustNote: Please reach out to us for more information about custom solutions.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:tranilast
- Products Intro:Purity: 99% | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Tranilast
- Products Intro:Purity: 0.99 | Package: 1kg,5kg,25kgs,200kgs;bulk
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Octane booster,lubricant additve,specialty chemicals,ingredients
$36.00-61.00
- Product Name:Tranilast
- Products Intro:Purity: 99.90% | Package: 5mg;36USD|10mg;50USD|25mg;61USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:tranilast
- Products Intro:Purity: 0.99 | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:tranilast
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Gamma-butyrolactone
- Product Name:Tranilast
- Products Intro:Purity: 99% | Package: USP EP CP
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmceutical,Optical Brightening,dyes
