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ChemicalBook >> CAS DataBase List >> L-trans-Pyrrolidine-2,4-dicarboxylic acid

L-trans-Pyrrolidine-2,4-dicarboxylic acid

L-trans-Pyrrolidine-2,4-dicarboxylic acid price.
  • $36 - $1170.31
  • Product name: L-trans-Pyrrolidine-2,4-dicarboxylic acid
  • CAS: 64769-66-0
  • MF: C6H9NO4
  • MW: 159.14
  • EINECS:
  • MDL Number:MFCD00153866
  • Synonyms:L-TRANS-4-CARBOXY-L-PROLINE;L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID;TRANS-4-CARBOXY-L-PROLINE;2,4-Pyrrolidinedicarboxylicacid,(2S,4R)-(9CI);Zinc03796127;(2S,4R)-pyrrolidine-2,4-dicarboxylic acid;(2S,4R)-2,4-Pyrrolidinedicarboxylic acid;2,4-Pyrrolidinedicarboxylic acid, (2S,4R)-
Price19 Properties Safety Information Description
19 prices
Selected condition：
Brand
  • aablocks
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 2mg
  • 1mg
  • 50
  • 2.5mg
  • 5MG
  • 10MG
  • 50MG
  • Manufactureraablocks
  • Product numberAA00E9IY
  • Product descriptionL-trans-Pyrrolidine-2,4-dicarboxylic Acid ≥98%
  • Packaging1mg
  • Price$36
  • Updated2026-05-28
  • Buy
  • ManufacturerAK Scientific
  • Product number9449BA
  • Product descriptiontrans-4-Carboxy-L-proline
  • Packaging1mg
  • Price$133
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCCH0004082
  • Product descriptionL-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID 95.00%
  • Packaging5MG
  • Price$232.1
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCCH0004082
  • Product descriptionL-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID 95.00%
  • Packaging10MG
  • Price$697.34
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCCH0004082
  • Product descriptionL-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID 95.00%
  • Packaging50MG
  • Price$1170.31
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6250
  • Product descriptionL-trans-2,4-PDC
  • Packaging50mg
  • Price$1053
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6250
  • Product descriptionL-trans-2,4-PDC
  • Packaging10mg
  • Price$251
  • Updated2026-05-06
  • Buy
  • ManufacturerCayman Chemical
  • Product number24268
  • Product descriptionL-trans-Pyrrolidine-2,4-dicarboxylic Acid ≥98%
  • Packaging1mg
  • Price$36
  • Updated2026-04-30
  • Buy
  • ManufacturerCayman Chemical
  • Product number24268
  • Product descriptionL-trans-Pyrrolidine-2,4-dicarboxylic Acid ≥98%
  • Packaging5mg
  • Price$86
  • Updated2026-04-30
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0020480
  • Product descriptiontrans-4-Carboxy-L-proline 99.9%
  • Packaging10mg
  • Price$546
  • Updated2026-06-04
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0020480
  • Product descriptiontrans-4-Carboxy-L-proline 99.9%
  • Packaging5mg
  • Price$321
  • Updated2026-06-04
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0020480
  • Product descriptiontrans-4-Carboxy-L-proline 99.9%
  • Packaging1mg
  • Price$83
  • Updated2026-06-04
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberP7575
  • Product descriptionL-trans-Pyrrolidine-2,4-dicarboxylic acid ≥98%
  • Packaging2mg
  • Price$80.2
  • Updated2026-04-30
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberP7575
  • Product descriptionL-trans-Pyrrolidine-2,4-dicarboxylic acid ≥98%
  • Packaging10mg
  • Price$257
  • Updated2026-04-30
  • Buy
  • ManufacturerTocris
  • Product number0298
  • Product descriptionL-trans-2,4-PDC ≥97%(HPLC)
  • Packaging10
  • Price$169
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number0298
  • Product descriptionL-trans-2,4-PDC ≥97%(HPLC)
  • Packaging50
  • Price$711
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00E9IY L-trans-Pyrrolidine-2,4-dicarboxylic Acid ≥98% 1mg $36 2026-05-28 Buy
AK Scientific 9449BA trans-4-Carboxy-L-proline 1mg $133 2021-12-16 Buy
American Custom Chemicals Corporation CCH0004082 L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID 95.00% 5MG $232.1 2021-12-16 Buy
American Custom Chemicals Corporation CCH0004082 L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID 95.00% 10MG $697.34 2021-12-16 Buy
American Custom Chemicals Corporation CCH0004082 L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID 95.00% 50MG $1170.31 2021-12-16 Buy
ApexBio Technology B6250 L-trans-2,4-PDC 50mg $1053 2026-05-06 Buy
ApexBio Technology B6250 L-trans-2,4-PDC 10mg $251 2026-05-06 Buy
Cayman Chemical 24268 L-trans-Pyrrolidine-2,4-dicarboxylic Acid ≥98% 1mg $36 2026-04-30 Buy
Cayman Chemical 24268 L-trans-Pyrrolidine-2,4-dicarboxylic Acid ≥98% 5mg $86 2026-04-30 Buy
ChemScene CS-0020480 trans-4-Carboxy-L-proline 99.9% 10mg $546 2026-06-04 Buy
ChemScene CS-0020480 trans-4-Carboxy-L-proline 99.9% 5mg $321 2026-06-04 Buy
ChemScene CS-0020480 trans-4-Carboxy-L-proline 99.9% 1mg $83 2026-06-04 Buy
Sigma-Aldrich P7575 L-trans-Pyrrolidine-2,4-dicarboxylic acid ≥98% 2mg $80.2 2026-04-30 Buy
Sigma-Aldrich P7575 L-trans-Pyrrolidine-2,4-dicarboxylic acid ≥98% 10mg $257 2026-04-30 Buy
Tocris 0298 L-trans-2,4-PDC ≥97%(HPLC) 10 $169 2021-12-16 Buy
Tocris 0298 L-trans-2,4-PDC ≥97%(HPLC) 50 $711 2021-12-16 Buy
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Properties

Melting point :214-217oC
storage temp. :Store at RT
solubility :PBS (pH 7.2): 2 mg/ml
form :White solid.
color :White
Water Solubility :Soluble to 100 mM in water
InChI :InChI=1S/C6H9NO4/c8-5(9)3-1-4(6(10)11)7-2-3/h3-4,7H,1-2H2,(H,8,9)(H,10,11)/t3-,4+/m1/s1
InChIKey :NRSBQSJHFYZIPH-DMTCNVIQSA-N
SMILES :N1C[C@H](C(O)=O)C[C@H]1C(O)=O

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

L-trans-Pyrrolidine-2,4-dicarboxylic acid (L-trans-PDC) is a glutamate uptake blocker, serving as a "conformer mimic" of the glutamate molecule as recognized by EAAT (excitatory amino acid transporter) proteins. L-trans-PDC is demonstrated to increase extracellular glutamate concentration without affecting extracellular GABA levels. Blockade of glutamate uptake by L-trans-PDC has a correlated effect of inducing neuronal Ca2+ influx and massive NMDA receptor-mediated neuronal death. Specificity of L-trans-PDC for the EAAT protein over other glutamate-recognizing loci indicates a particular structural requirement for the EAAT binding site, satisfied by this structurally rigid pyrrolidine "conformer mimic" of glutamate. L-trans-Pyrrolidine-2,4-dicarboxylic acid is an inhibitor of EAAT1, EAAT2, EAAT3, EAAT4 and EAAT5.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
L-trans-2,4-PDC
$113.00
L-trans-2,4-PDC CAS:64769-66-0
3B Pharmachem (Wuhan) International Co.,Ltd. BOC Sciences Guangzhou Isun Pharmaceutical Co., Ltd EMMX Biotechnology LLC Shanghai EFE Biological Technology Co., Ltd. Capot Chemical Co.,Ltd. Nextpeptide Inc ChemeGen(Shanghai) Biotechnology Co.,Ltd. Haiji Pharmaceutical Technology (Suzhou) Co., Ltd