L-trans-Pyrrolidine-2,4-dicarboxylic acid
- CAS No.
- 64769-66-0
- Chemical Name:
- L-trans-Pyrrolidine-2,4-dicarboxylic acid
- Synonyms
- L-TRANS-2,4-PDC;4-PDC;L-trans-2;Zinc03796127;TRANS-4-CARBOXY-L-PROLINE;L-TRANS-4-CARBOXY-L-PROLINE;Ltrans2,4PDC,L trans 2,4 PDC;(2S,4R)-2,4-Pyrrolidinedicarboxylic acid;L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID;(2S,4R)-pyrrolidine-2,4-dicarboxylic acid
- CBNumber:
- CB3230189
- Molecular Formula:
- C6H9NO4
- Molecular Weight:
- 159.14
- MDL Number:
- MFCD00153866
- MOL File:
- 64769-66-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 214-217oC |
|---|---|
| storage temp. | Store at RT |
| solubility | PBS (pH 7.2): 2 mg/ml |
| form | White solid. |
| color | White |
| Water Solubility | Soluble to 100 mM in water |
| InChI | InChI=1S/C6H9NO4/c8-5(9)3-1-4(6(10)11)7-2-3/h3-4,7H,1-2H2,(H,8,9)(H,10,11)/t3-,4+/m1/s1 |
| InChIKey | NRSBQSJHFYZIPH-DMTCNVIQSA-N |
| SMILES | N1C[C@H](C(O)=O)C[C@H]1C(O)=O |
| UNSPSC Code | 12352106 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
L-trans-Pyrrolidine-2,4-dicarboxylic acid price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P7575 | L-trans-Pyrrolidine-2,4-dicarboxylic acid ≥98% | 64769-66-0 | 2mg | $80.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | P7575 | L-trans-Pyrrolidine-2,4-dicarboxylic acid ≥98% | 64769-66-0 | 10mg | $257 | 2026-04-30 | Buy |
| Cayman Chemical | 24268 | L-trans-Pyrrolidine-2,4-dicarboxylic Acid ≥98% | 64769-66-0 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 24268 | L-trans-Pyrrolidine-2,4-dicarboxylic Acid ≥98% | 64769-66-0 | 5mg | $86 | 2026-04-30 | Buy |
| Usbiological | 255657 | L-trans-2,4-PDC Asreported | 64769-66-0 | 10mg | $423 | 2026-06-03 | Buy |
L-trans-Pyrrolidine-2,4-dicarboxylic acid Chemical Properties, Uses, Production
Description
L-trans-Pyrrolidine-2,4-dicarboxylic acid (L-trans-2,4-PDC) is an inhibitor of L-glutamate transport (Ki = 4.6 μM in rat brain synaptosomes). It inhibits radioligand binding to NMDA receptors by 13% but has no effect on AMPA or kainate receptors when used at a concentration of 100 μM. L-trans-2,4-PDC is neurotoxic to astrocyte-rich and astrocyte-poor rat cortical cultures (EC50s = 320 and 50 μM, respectively), an effect that can be reversed by the NMDA antagonist MK-801 and glutamate-pyruvate transaminase but not the non-NMDA glutamate receptor antagonist CNQX. It induces efflux of the non-metabolizable glutamate analog [3H]-D-aspartate in an extracellular sodium-dependent manner. In vivo, L-trans-2,4-PDC (0.05-0.2 μg/side) prevents amphetamine-induced hyperlocomotion in a dose-dependent manner in rats when injected directly into the nucleus accumbens. It also increases bladder intercontraction interval (ICI) without affecting postvoid residual or basal pressure in rats.
Uses
L-trans-Pyrrolidine-2,4-dicarboxylic Acid is an inhibitor of the glutamate transporter EAAT.
Biological Activity
Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ .
storage
Store at RT
References
[1] RICHARD J. BRIDGES. Conformationally defined neurotransmitter analogs. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer[J]. Journal of Medicinal Chemistry, 1991, 34 2: 717-725. DOI:10.1021/jm00106a037.
[2] Blitzblau, R., Gupta, S., Djali, S., et al. The glutamate transport inhibitor L-trans-pyrrolidine-2,4-dicarboxylate indirectly evokes NMDA receptor mediated neurotoxicity in rat cortical cultures. Eur. J. Neurosci. 8(9), 1840-1852 (1996).
[3] David, H.N., Thévenoux, A., and Abraini, J.H. Inhibition of the glutamate transporter by L-trans-PDC in the nucleus accumbens prevents the locomotor response to amphetamine. Neuropharmacology 41(3), 409-411 (2001).
[4] MASASHI HONDA. Supraspinal and spinal effects of L-trans-PDC, an inhibitor of glutamate transporter, on the micturition reflex in rats.[J]. Neurourology and Urodynamics, 2013, 32 7: 1026-1030. DOI:10.1002/nau.22351.
L-trans-Pyrrolidine-2,4-dicarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19904 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Haiji Pharmaceutical Technology (Suzhou) Co., Ltd | 18012778619 | 3394205705@qq.com | China | 9821 | 58 |
View Latest Price from L-trans-Pyrrolidine-2,4-dicarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | L-trans-2,4-PDC
64769-66-0
|
$113.00-282.00 | 10g | TargetMol Chemicals Inc. |
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- L-trans-2,4-PDC
64769-66-0
- $113.00-282.00
- TargetMol Chemicals Inc.
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