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ChemicalBook >> CAS DataBase List >> KRN 633

KRN 633

KRN 633 price.
  • $8 - $21021
  • Product name: KRN 633
  • CAS: 286370-15-8
  • MF: C20H21ClN4O4
  • MW: 416.86
  • EINECS:
  • MDL Number:MFCD14155620
  • Synonyms:KRN 633;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea;1-(2-chloro-4-(6,7-diMethoxyquinazolin-4-yloxy)phenyl)-3-propylurea;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea KRN633;VEGFR Tyrosine Kinase Inhibitor III, KRN633;KRN 633;KRN-633;CS-463;KRN633; KRN-633; KRN 633
Price46 Properties Safety Information Description
46 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 10mM(in1mLDMSO)
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 1KG
  • Manufactureraablocks
  • Product numberAA002VU8
  • Product description1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea 98%
  • Packaging1mg
  • Price$8
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002VU8
  • Product description1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea ≥97%
  • Packaging5mg
  • Price$12
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002VU8
  • Product description1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea 98%
  • Packaging10mg
  • Price$22
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002VU8
  • Product description1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea ≥97%
  • Packaging25mg
  • Price$43
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA002VU8
  • Product description1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea ≥97%
  • Packaging100mg
  • Price$136
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberM15307
  • Product descriptionKRN 633 98%
  • Packaging25MG
  • Price$110
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberM15307
  • Product descriptionKRN 633 98%
  • Packaging100MG
  • Price$215
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product numberX7494
  • Product descriptionKRN633
  • Packaging10mg
  • Price$178
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA263491
  • Product descriptionKRN-633 98+%
  • Packaging50mg
  • Price$149
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA263491
  • Product descriptionKRN-633 98+%
  • Packaging100mg
  • Price$201
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA263491
  • Product descriptionKRN-633 98+%
  • Packaging1mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA263491
  • Product descriptionKRN-633 98+%
  • Packaging5mg
  • Price$68
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA263491
  • Product descriptionKRN-633 98+%
  • Packaging10mg
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA263491
  • Product descriptionKRN-633 98+%
  • Packaging250mg
  • Price$396
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA263491
  • Product descriptionKRN-633 98+%
  • Packaging1g
  • Price$1032
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000143
  • Product descriptionKRN 633 95.00%
  • Packaging1KG
  • Price$21021
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA002VU8 1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea 98% 1mg $8 2026-05-28 Buy
aablocks AA002VU8 1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea ≥97% 5mg $12 2026-05-28 Buy
aablocks AA002VU8 1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea 98% 10mg $22 2026-05-28 Buy
aablocks AA002VU8 1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea ≥97% 25mg $43 2026-05-28 Buy
aablocks AA002VU8 1-{2-Chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea ≥97% 100mg $136 2026-05-28 Buy
ACHEMBLOCK M15307 KRN 633 98% 25MG $110 2026-05-27 Buy
ACHEMBLOCK M15307 KRN 633 98% 100MG $215 2026-05-27 Buy
AK Scientific X7494 KRN633 10mg $178 2021-12-16 Buy
Ambeed A263491 KRN-633 98+% 50mg $149 2021-12-16 Buy
Ambeed A263491 KRN-633 98+% 100mg $201 2021-12-16 Buy
Ambeed A263491 KRN-633 98+% 1mg $40 2021-12-16 Buy
Ambeed A263491 KRN-633 98+% 5mg $68 2021-12-16 Buy
Ambeed A263491 KRN-633 98+% 10mg $88 2021-12-16 Buy
Ambeed A263491 KRN-633 98+% 250mg $396 2021-12-16 Buy
Ambeed A263491 KRN-633 98+% 1g $1032 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000143 KRN 633 95.00% 1KG $21021 2021-12-16 Buy
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Properties

Melting point :231-232°C
Boiling point :545.6±50.0 °C(Predicted)
Density :1.321
storage temp. :-20°C
solubility :DMSO: soluble3mg/mL, clear (warmed)
pka :13.08±0.70(Predicted)
form :powder
color :white to beige
InChI :1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26)
InChIKey :VPBYZLCHOKSGRX-UHFFFAOYSA-N

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

KRN 633 is an ATP-competitive inhibitor of VEGFR kinase activity (IC50s = 170, 160, and 125 nM for VEGFR1, 2, and 3, respectively). At higher concentrations KRN 633 inhibits PDGFR-α and c-KIT with IC50 values of 0.97 and 4.3 μM, respectively, and is inactive towards a panel of 17 additional kinases. KRN 633 suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.

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Suppliers and manufacturers

Shanghai Boyle Chemical Co., Ltd. WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. Jinan Trio PharmaTech Co., Ltd. BOC Sciences Dalian Meilun Biotech Co., Ltd. Haoyuan Chemexpress Co., Ltd. TOKYO CHEMICAL INDUSTRY CO., LTD. TCI Europe Shanghai Aladdin Bio-Chem Technology Co.,LTD The future of Shanghai Industrial Co., Ltd.