Selumetinib
|
- $25 - $3538
- Product name: Selumetinib
- CAS: 606143-52-6
- MF: C17H15BrClFN4O3
- MW: 457.68
- EINECS:207-313-3
- MDL Number:MFCD11977472
- Synonyms:ARRY 142886;AZD 6244;5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide;6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide;Selumetinib AZD624;5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-car;Selumetinib, 99%, a highly selective MEK1 inhibitor;Selumetinib, Free BaseAZD6244ARRY-142886
54 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
Package
- 20mg
- 200mg
- 250mg
- 50
- 1g
- 2g
- 5g
- 100g
- 10mM(in1mLDMSO)
- 1mg
- 5mg
- 10mg
- 50mg
- 100mg
- 10mM(in 1mL DMSO)
- 25mg
- 500mg
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3757-M010
- Product descriptionSelumetinib ≥98%(HPLC)
- Packaging10mg
- Price$25
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3757-M050
- Product descriptionSelumetinib ≥98%(HPLC)
- Packaging50mg
- Price$70
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1016-M001
- Product descriptionSelumetinib ≥95%
- Packaging1mg
- Price$96
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1016-M005
- Product descriptionSelumetinib ≥95%
- Packaging5mg
- Price$144
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1016-M010
- Product descriptionSelumetinib ≥95%
- Packaging10mg
- Price$216
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1016-M010
- Product descriptionSelumetinib ≥95%
- Packaging10mg
- Price$239
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1016-M050
- Product descriptionSelumetinib ≥95%
- Packaging50mg
- Price$706
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product numberJ98068
- Product descriptionSelumetinib
- Packaging100mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ98068
- Product descriptionSelumetinib
- Packaging25mg
- Price$44
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000550
- Product descriptionAZD-6244 95.00%
- Packaging25MG
- Price$704.11
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000550
- Product descriptionAZD-6244 95.00%
- Packaging1MG
- Price$203.7
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8207
- Product descriptionAZD6244 (Selumetinib)
- Packaging500mg
- Price$297
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8207
- Product descriptionAZD6244(Selumetinib)
- Packaging500mg
- Price$270
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8207
- Product descriptionAZD6244(Selumetinib)
- Packaging10mM(in 1mL DMSO)
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8207
- Product descriptionAZD6244(Selumetinib)
- Packaging100mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8207
- Product descriptionAZD6244 (Selumetinib)
- Packaging100mg
- Price$88
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3757-M010 | Selumetinib ≥98%(HPLC) | 10mg | $25 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3757-M050 | Selumetinib ≥98%(HPLC) | 50mg | $70 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1016-M001 | Selumetinib ≥95% | 1mg | $96 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1016-M005 | Selumetinib ≥95% | 5mg | $144 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1016-M010 | Selumetinib ≥95% | 10mg | $216 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1016-M010 | Selumetinib ≥95% | 10mg | $239 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1016-M050 | Selumetinib ≥95% | 50mg | $706 | 2026-05-06 | Buy |
| AK Scientific | J98068 | Selumetinib | 100mg | $96 | 2021-12-16 | Buy |
| AK Scientific | J98068 | Selumetinib | 25mg | $44 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000550 | AZD-6244 95.00% | 25MG | $704.11 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000550 | AZD-6244 95.00% | 1MG | $203.7 | 2021-12-16 | Buy |
| ApexBio Technology | A8207 | AZD6244 (Selumetinib) | 500mg | $297 | 2026-05-06 | Buy |
| ApexBio Technology | A8207 | AZD6244(Selumetinib) | 500mg | $270 | 2021-12-16 | Buy |
| ApexBio Technology | A8207 | AZD6244(Selumetinib) | 10mM(in 1mL DMSO) | $55 | 2021-12-16 | Buy |
| ApexBio Technology | A8207 | AZD6244(Selumetinib) | 100mg | $80 | 2021-12-16 | Buy |
| ApexBio Technology | A8207 | AZD6244 (Selumetinib) | 100mg | $88 | 2026-05-06 | Buy |
Properties
Melting point :>219°C (dec.)
Density :1.69
storage temp. :-20°
solubility :Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml)
pka :14.20±0.10(Predicted)
form :Beige powder.
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChIKey :CYOHGALHFOKKQC-UHFFFAOYSA-N
SMILES :C1N(C)C2=CC(C(NOCCO)=O)=C(NC3=CC=C(Br)C=C3Cl)C(F)=C2N=1
Density :1.69
storage temp. :-20°
solubility :Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml)
pka :14.20±0.10(Predicted)
form :Beige powder.
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChIKey :CYOHGALHFOKKQC-UHFFFAOYSA-N
SMILES :C1N(C)C2=CC(C(NOCCO)=O)=C(NC3=CC=C(Br)C=C3Cl)C(F)=C2N=1
Safety Information
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| Signal word: | Danger | ||||||||||||||||||||||||||||
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Description
MEK kinases are central components of diverse intracellular signaling pathways. MEK1 and MEK2 specifically act downstream of growth factor receptors and the proto-oncogenes Ras and Raf to activate ERK1 and ERK2, often leading to an increase in cell proliferation. AZD 6244 is a potent, highly selective inhibitor of MEK1 and MEK2 (IC50 = 14 and 530 nM, respectively). It weakly inhibits the EGF receptor (IC50 = 7.0 μM) and has no effect on a large panel of other kinases. AZD 6244 suppresses the growth of tumors displaying high levels of phosphorylated MEK1/2 or ERK1/2. In addition to suppressing growth, it induces apoptosis and differentiation within tumors. AZD 6244 has potential, alone or in combination therapy, for promoting tumor regression in various forms of cancer, including those involving mutations of the proto-oncogenes Ras and Raf.Related product price
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Suppliers and manufacturers
Capot Chemical Co.,Ltd.
Nanjing Finetech Chemical Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
