| Company Name: |
BOC Sciences |
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1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
- JX 401
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- $198.00
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2026-07-27
- CAS:349087-34-9
- Purity:
- Supply Ability: 10g
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| Product Name: | JX401 | | Synonyms: | JX401;1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine;1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine;p38 MAP Kinase Inhibitor VI, JX401;p38 MAP Kinase Inhibitor VI, JX401 - CAS 349087-34-9 - Calbiochem;Methanone, [2-methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]-;JX-401, p38alpha inhibitor | | CAS: | 349087-34-9 | | MF: | C21H25NO2S | | MW: | 355.49 | | EINECS: | | | Product Categories: | Intracellular Signaling | | Mol File: | 349087-34-9.mol |  |
| | JX401 Chemical Properties |
| storage temp. | Store at RT | | solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml). | | form | Off-white solid | | color | White | | Stability: | Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. | | InChI | 1S/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3 | | InChIKey | OMGLGPKQUFSRNN-UHFFFAOYSA-N |
| Hazard Codes | N | | Risk Statements | 50/53 | | Safety Statements | 60-61 | | RIDADR | UN 3077 9/PG 3 | | WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | JX401 Usage And Synthesis |
| Description | JX401 (349087-34-9) is a potent, cell-permeable inhibitor of p38α (IC50 = 32 nM). No inhibition of p38β was observed at 10 μM. | | Uses | JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). It does not inhibit the p38γ isoform. JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.[Cayman Chemical] | | Uses | JX-401 is an inhibitor of p38α isoform MAP kinase, blocks the differentiation of myoblasts and myotubes. | | Definition | ChEBI: [2-methoxy-4-(methylthio)phenyl]-[4-(phenylmethyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides. | | Biological Activity | Potent, reversible inhibitor of p38 α that displays no activity on the p38 γ isoform (IC 50 values are 32 nM and > 10 μ M respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture. | | storage | Room temperature | | References | [1] YAEL FRIEDMANN. JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast.[J]. Molecular Pharmacology, 2006, 70 4: 1395-1405. DOI:10.1124/mol.106.022962 |
| | JX401 Preparation Products And Raw materials |
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