- SB 239063
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- $43.00 / 1mg
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2025-09-22
- CAS:193551-21-2
- Min. Order:
- Purity: 99.81%
- Supply Ability: 10g
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| | SB 239063 Basic information |
| Product Name: | SB 239063 | | Synonyms: | SB 239063;TRANS-1-(4-HYDROXYCYCLOHEXYL)-4-(4-FLUOROPHENYL)-5-(2-METHOXYPYRIDIMIDIN-4-YL)IMIDAZOLE;TRANS-1-(4-HYDROXYCYCLOHEXYL)-4-(4-FLUOROPHENYL)-5-(2-METHOXYPYRIMIDIN-4-YL) IMIDAZOLE;TRANS-1-(4-HYDROXYCYCLOHEXYL)-4-(FLUOROPHENYL)-5-(2-METHOXYPYRIMIDIN-4-YL) IMIDAZOLE;TRANS-4-[4-(4-FLUOROPHENYL)-5-(2-METHOXY-4-PYRIMIDINYL)-1H-IMIDAZOL-1-YL]CYCLOHEXANOL;Cyclohexanol, 4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-, trans-;SB 239063 - CAS 798558-40-4 - Calbiochem;CS-402 | | CAS: | 193551-21-2 | | MF: | C20H21FN4O2 | | MW: | 368.4 | | EINECS: | | | Product Categories: | Aromatics;Heterocycles;Protein Kinase Inhibitors and Activators | | Mol File: | 193551-21-2.mol |  |
| | SB 239063 Chemical Properties |
| Melting point | 206-207.2 °C | | storage temp. | 2-8°C | | solubility | DMSO: 11 mg/mL | | form | White solid | | color | white | | InChI | InChI=1S/C20H21FN4O2/c1-27-20-22-11-10-17(24-20)19-18(13-2-4-14(21)5-3-13)23-12-25(19)15-6-8-16(26)9-7-15/h2-5,10-12,15-16,26H,6-9H2,1H3/t15-,16- | | InChIKey | ZQUSFAUAYSEREK-WKILWMFISA-N | | SMILES | [C@@H]1(O)CC[C@@H](N2C=NC(C3=CC=C(F)C=C3)=C2C2C=CN=C(OC)N=2)CC1 |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | GV9458000 | | HS Code | 2933599590 |
| | SB 239063 Usage And Synthesis |
| Uses | SB239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen-glucose-deprived hippocampal slice cultures. A protein kinase inhibitor | | Uses | SB 239063 has been used to determine the roles of c-Jun N-terminal kinase (JNK), p38 MAP kinase, and extracellular signal regulated protein kinase (ERK)/p42/p44 mitogen activated protein kinase (MAPK) on the viability and apoptosis of cardiomyocytes under glutathione S-transferase (GST) inhibition. It has also been used in neuron-microglia conditioned media (CM) experiments and pharmacokinetics. | | Definition | ChEBI: A member of the class of imidazoles carrying 4-hydroxycyclohexyl, 4-fluorophenyl and 2-methoxypyrimidin-4-yl substituents at positions 1, 4 and 5 respectively. | | General Description | SB 239063 helps to decrease neutrophilia, inflammatory cytokines, matrix metallopeptidase 9 (MMP-9) and fibrosis in the lung. | | Hazard | A poison by ingestion. | | Biological Activity | Potent and selective p38 MAP kinase inhibitor (IC 50 = 44 nM for p38a). Displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580 (4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-i midazol-4-yl]pyridine and 4-[5-(4-Fluorophenyl)-2-[4-(methylsulphonyl)phenyl]-1H- imidazol-4-yl]pyridine hydrochloride
). Reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo . | | Biochem/physiol Actions | Potent p38 MAP kinase inhibitor. Selective for α and β. No activity against γ and δ isoforms. | | Synthesis | The general procedure for the synthesis of (1r,4r)-rel-4-(4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)-1H-imidazol-1-yl)cyclohexanol, using the compound (CAS: 193551-20-1) as a starting material was as follows:
Example 2: Synthesis of trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)imidazole
To a solution of the compound prepared in Example 1 (j) (0.099 g, dissolved in MeOH/THF (1 mL, 1:1 volume ratio), corresponding to 0.27 mmol) was added a NaBH4 solution (1 mL, 1 M solution. This NaBH4 solution was prepared by mixing 0.10 g NaBH4, MeOH (2.5 mL) and 25% NaOMe in MeOH solution (0.2 mL)). The reaction mixture was stirred for 10 min and then the reaction was quenched with saturated Na2CO3 solution, followed by evaporation to remove the solvent. The residue was purified by recrystallization from the mixed MeOH/H2O solvent to afford the target product (1r,4r)-rel-4-(4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)-1H-imidazol-1-yl)cyclohexanol as white acicular crystals (0.063 g, 63% yield). The melting point of the product was 188-190 °C. | | in vitro | in oxygen-glucose-deprived hippocampal slice cultures, treatment with 20 μm and 100 μm sb239063 significantly reduced the levels of the pro-inflammatory cytokine il-1β and reduced cell death after oxygen-glucose deprivation and strikingly diminished microglia activation[2]. | | in vivo | oral administration of 3–30 mg/kg sb 239063 given twice a day dose-dependently inhibited airway neutrophil infiltration and interleukin (il)-6 levels 48 h after lipopolysaccharide (lps) inhalation [1]. in a bleomycin-induced pulmonary fibrosis model rats, sb 239063 treatment (2.4 or 4.8 mg/day via osmotic pump) significantly inhibited bleomycin-induced right ventricular hypertrophy (indicative of secondary pulmonary hypertension) and increased in lung hydroxyproline synthesis (indicative of collagen synthesis and fibrosis) (1). in conscious guinea pigs, administration of sb 239063 (10 or 30 mg/kg p.o.) showed approximately 50% inhibition of oa-induced pulmonary eosinophil influx, measured by bal 24 h after antigen(1). orally administration of sb 239063 (30 mg/kg) attenuated il-6 bronchoalveolar lavage fluid concentrations (> 90% inhibition) and mmp-9 activity (64% inhibition) measured 6 h after lps exposure. in guinea pig cultured alveolar macrophages, sb 239063 inhibited lps-induced il-6 production with ic50 of 362 nm. in lipopolysaccharide-stimulated human peripheral blood monocytes, sb 239063 inhibited il-1 and tnf-α production with an ic50 of 0.12 and 0.35 μm, respectively(1). | | storage | Desiccate at +4°C | | references | [1] underwood d c, osborn r r, bochnowicz s, et al. sb 239063, a p38 mapk inhibitor, reduces neutrophilia, inflammatory cytokines, mmp-9, and fibrosis in lung[j]. american journal of physiology-lung cellular and molecular physiology, 2000, 279(5): l895-l902.
[2] strassburger m, braun h, reymann k g. anti-inflammatory treatment with the p38 mitogen-activated protein kinase inhibitor sb239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen–glucose-deprived hippocampal slice cultures[j]. european journal of pharmacology, 2008, 592(1): 55-61. |
| | SB 239063 Preparation Products And Raw materials |
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