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| | (S)-N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid Basic information |
| Product Name: | (S)-N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid | | Synonyms: | (S)-Piperazine-1,2,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester;(S)-N-4-Boc-N-1-Cbz-2-Piperazinecarboxylic acid;1,2,4-Piperazinetricarboxylic acid, 4-(1,1-diMethylethyl) 1-(phenylMethyl) ester, (2S)-;(2S)-1-[(benzyloxy)carbonyl]-4-[(tert-butoxy)carbonyl]piperazine-2-carboxylic acid;S-1-cbz-4-Boc-2-piperazinecarboxylate;(S)-1-((Benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid - [B91338] | | CAS: | 150407-69-5 | | MF: | C18H24N2O6 | | MW: | 364.39 | | EINECS: | | | Product Categories: | Piperazines | | Mol File: | 150407-69-5.mol |  |
| | (S)-N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid Chemical Properties |
| storage temp. | 2-8°C | | Appearance | White to off-white Solid |
| | (S)-N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid Usage And Synthesis |
| Synthesis | To a solution of 1-tert-butyl piperazine-1,3-dicarboxylate (4.5 g, 19.565 mmol, 1.0 eq.) in dichloromethane (DCM, 125 mL) were sequentially added triethylamine (TEA, 5.93 g, 58.70 mmol, 3.0 eq.) and benzyl chloroformate (CbzCl, 5 g, 29.35 mmol, 3.0 eq.). The reaction mixture was stirred at room temperature for 4 h, during which the reaction progress was monitored by liquid chromatography-mass spectrometry (LC-MS) and thin layer chromatography (TLC). Upon completion of the reaction, the mixture was concentrated and the resulting residue was purified by silica gel column chromatography (eluent ratio: petroleum ether/ethyl acetate = 5/1) to afford the target product (S)-1-((benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (5 g, 70% yield) as a white solid. | | References | [1] Patent: WO2017/98328, 2017, A2. Location in patent: Paragraph 00276 |
| | (S)-N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid Preparation Products And Raw materials |
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