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CHEMICAL LAND21
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82- 2 -783 - 8063 |
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sales21@chemicalland21.com |
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| | inophyllum B Basic information |
| Product Name: | inophyllum B | | Synonyms: | inophyllum B;2H,6H,10H-Benzo[1,2-b:3,4-b':5,6-b'']tripyran-2-one, 11,12-dihydro-12-hydroxy-6,6,10,11-tetramethyl-4-phenyl-, (10R,11S,12S)- | | CAS: | 41135-06-2 | | MF: | C25H24O5 | | MW: | 404.46 | | EINECS: | | | Product Categories: | | | Mol File: | 41135-06-2.mol |  |
| | inophyllum B Chemical Properties |
| Melting point | 58-62 °C | | Boiling point | 564.7±50.0 °C(Predicted) | | density | 1.249±0.06 g/cm3(Predicted) | | pka | 13.37±0.70(Predicted) |
| | inophyllum B Usage And Synthesis |
| Uses | Inophyllum B ((+)-Inophyllum B) is a potent HIV Reverse Transcriptase inhibitor with an IC50 value of 38 nM. Inophyllum B inhibits HIV-1 (IC50=1.4 μM) in vitro cell culture. Inophyllum B can be isolated from the acetone extract of the giant African snail, Achatina fulica[1]. | | IC 50 | HIV-1: 1.4 μM (IC50); Reverse Transcriptase: 38 nM (IC50) | | References | [1] Patil AD, et al. The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn. J Med Chem. 1993 Dec 24;36(26):4131-8. DOI:10.1021/jm00078a001 |
| | inophyllum B Preparation Products And Raw materials |
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