4-Bromo-benzo[b]thiophene-2-carboxylic acid

4-Bromo-benzo[b]thiophene-2-carboxylic acid Suppliers list

Company Name:	Sichuan Fanzhijian Biomedical Technology Co., Ltd Gold
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Company Name:	Meryer (Shanghai) Chemical Technology Co., Ltd.
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4-Bromo-benzo[b]thiophene-2-carboxylic acid manufacturers

4-Bromo-benzo[b]thiophene-2-carboxylic acid Basic information

Product Name:	4-Bromo-benzo[b]thiophene-2-carboxylic acid
Synonyms:	Benzo[b]thiophene-2-carboxylic acid, 4-bromo-;4-Bromobenzothiophene-2-carboxylic acid;4-Bromobenzo[b]thiophene-2-carboxylicaci;4-BROMO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID;4-Bromo-benzo[b]thiophene-2-carboxylic acid
CAS:	5194-37-6
MF:	C9H5BrO2S
MW:	257.1
EINECS:	1592732-453-0
Product Categories:
Mol File:	5194-37-6.mol

4-Bromo-benzo[b]thiophene-2-carboxylic acid Chemical Properties

Melting point	265
Boiling point	429.7±25.0 °C(Predicted)
density	1.813±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
form	powder
pka	3.27±0.30(Predicted)
color	White
InChI	InChI=1S/C9H5BrO2S/c10-6-2-1-3-7-5(6)4-8(13-7)9(11)12/h1-4H,(H,11,12)
InChIKey	LAYNZUFIYSYHIV-UHFFFAOYSA-N
SMILES	C12=CC=CC(Br)=C1C=C(C(O)=O)S2

Safety Information

MSDS Information

4-Bromo-benzo[b]thiophene-2-carboxylic acid Usage And Synthesis

Uses	4-BROMO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID can be used as a key intermediate in the synthesis of pharmaceuticals. It has potentially biological activity.
Synthesis	93103-82-3 5194-37-6 Step 3: (0367) To a 500 mL single neck flask was added ethyl 4-bromo-1-benzothiophene-2-carboxylate (20 g, 70.4 mmol), tetrahydrofuran (120 mL) and water (100 mL). Aqueous 4 N sodium hydroxide (40 mL) was added slowly with stirring, followed by heating the reaction mixture to 70 °C with continuous stirring for 1 hour. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (70 mL x 2). The pH of the aqueous phase was adjusted to 12 with concentrated hydrochloric acid and the precipitated solid was filtered and dried to give 4-bromobenzo[b]thiophene-2-carboxylic acid (16 g, yield: 88%).
References	[1] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984, vol. 23, # 1, p. 38 - 41 [2] Patent: US2017/158680, 2017, A1. Location in patent: Paragraph 0361; 0366; 0367

4-Bromo-benzo[b]thiophene-2-carboxylic acid Preparation Products And Raw materials

Raw materials	Ethyl 4-broMo-1-benzothiophene-2-carboxylate-->2-Bromo-6-fluorobenzaldehyde-->4-Bromo-benzo[b]thiophene-2-carboxylic acid methyl ester-->Thioglycolic acid-->Water-->Tetrahydrofuran-->Sodium hydroxide
Preparation Products	4-Bromo-1-benzothiophene-2-carbonyl chloride-->Ethyl 4-broMo-1-benzothiophene-2-carboxylate

Tag:4-Bromo-benzo[b]thiophene-2-carboxylic acid(5194-37-6) Related Product Information

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