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| | 4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride Basic information |
| Product Name: | 4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride | | Synonyms: | Tetrahydro-2H-thiopyran-4-amine 1,1-dioxide hydrochloride, 4-Amino-1,1-dioxidothiane hydrochloride;4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride hydrochloride;1,1-dioxo-tetrahydrothiopyran-4-amine hydrochloride;1,1-Dioxo-tetrahydro-2H-thiopyran-4-amine HCl;4-AMINOTETRAHYDRO-2H-THIOPYRAN 1,1-DIOXIDE HYDROCHLORIDE;4-AMinotetrahydro-2H-thiopyran 1,1-dioxide HCl;4-aMino-1$l^{6}-thiane-1,1-dione hydrochloride;2H-Thiopyran-4-aMine, tetrahydro-, 1,1-dioxide, hydrochloride | | CAS: | 116529-31-8 | | MF: | C5H12ClNO2S | | MW: | 185.67 | | EINECS: | | | Product Categories: | | | Mol File: | 116529-31-8.mol |  |
| | 4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride Chemical Properties |
| Melting point | 289 °C | | storage temp. | Inert atmosphere,Room Temperature | | Water Solubility | Soluble in water | | form | powder to crystal | | color | White to Almost white | | InChI | 1S/C5H11NO2S.ClH/c6-5-1-3-9(7,8)4-2-5;/h5H,1-4,6H2;1H | | InChIKey | XUECUYGAJXDZKG-UHFFFAOYSA-N | | SMILES | O=S1(CCC(N)CC1)=O.Cl | | CAS DataBase Reference | 116529-31-8 |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | WGK 3 | | HS Code | 2930909899 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride Usage And Synthesis |
| Uses | 4-Aminotetrahydro-2H-thiopyran 1,1-dioxide, HCl | | Synthesis | The general procedure for the synthesis of 4-aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride from tert-butyl (1,1-dioxidotetrahydro-2H-thiopyran-4-yl)carbamate was as follows: tert-butyl (1,1-dioxidotetrahydro-2H-thiopyran-4-yl)carbamate (3.14 g) was dissolved in ethyl acetate (110 mL) that was preheated to 50 °C, to which a solution was subsequently 4M HCl-ethyl acetate solution (30 mL) was added. The reaction mixture was stirred at room temperature for 19 hours. Upon completion of the reaction, the precipitated white crystals were collected by filtration and washed with ethyl acetate. Finally, the product was dried under reduced pressure to afford 4-aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride (2.39 g, 100% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 1.93-2.11 (2H, m), 2.23 (2H, d, J=14.4 Hz), 3.08-3.21 (2H, m), 3.21-3.46 (3H, m), 8.10 (3H, br.s.). | | References | [1] Patent: EP2261213, 2010, A1. Location in patent: Page/Page column 53
[2] Patent: EP1486490, 2004, A1. Location in patent: Page 45
[3] Patent: WO2008/34860, 2008, A1. Location in patent: Page/Page column 104
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 8, p. 3548 - 3571
[5] Patent: WO2008/145688, 2008, A2. Location in patent: Page/Page column 92 |
| | 4-Aminotetrahydro-2H-thiopyran 1,1-dioxide hydrochloride Preparation Products And Raw materials |
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