- 4-IODO-2-PYRIDONE
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- $5.00 / 1KG
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2020-01-13
- CAS:858839-90-4
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 100KG
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| | 4-IODO-2-PYRIDONE Basic information |
| Product Name: | 4-IODO-2-PYRIDONE | | Synonyms: | 4-IODO-2-PYRIDONE;4-Iodo-2(1H)-pyridinone;4-Iodo-2-hydroxypyridine;4-iodo-2-pyridone , 97+%;4-iodo-1,2-dihydropyridin-2-one;2-Hydroxy-4-iodopyridine;4-Iodopyridin-2(1H);4-Iodo-2-pyridinone | | CAS: | 858839-90-4 | | MF: | C5H4INO | | MW: | 221 | | EINECS: | 690-950-8 | | Product Categories: | Halides;Pyridines | | Mol File: | 858839-90-4.mol |  |
| | 4-IODO-2-PYRIDONE Chemical Properties |
| Melting point | 186-188°C | | Boiling point | 321.6±35.0 °C(Predicted) | | density | 2.12±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | solid | | pka | 10.76±0.10(Predicted) | | color | Pale brown | | InChI | 1S/C5H4INO/c6-4-1-2-7-5(8)3-4/h1-3H,(H,7,8) | | InChIKey | POHJRJNCZQENQG-UHFFFAOYSA-N | | SMILES | O=C1C=C(I)C=CN1 | | CAS DataBase Reference | 858839-90-4 |
| WGK Germany | WGK 3 | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids |
| | 4-IODO-2-PYRIDONE Usage And Synthesis |
| Synthesis | GENERAL METHOD: 2-chloro-4-iodopyridine (prepared above) was heated with sodium acetate (2.0 eq.) in 1.0 M acetic acid solution at 150°C for 72 hours in a sealed tube. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The residue was partitioned between ethyl acetate (3 mL/mmol) and cold water (3 mL/mmol). The aqueous layer was extracted with ethyl acetate (3 mL/mmol; 4 times). The combined organic layers were washed sequentially with saturated NaHCO3 solution (1 mL/mmol), brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography to afford 4-iodo-2-pyridinone (1b/c/d), details of the specific compound are given below. | | References | [1] Synlett, 2016, vol. 27, # 1, p. 67 - 69
[2] Patent: US2010/331320, 2010, A1. Location in patent: Page/Page column 89; 90
[3] Patent: WO2015/101928, 2015, A1. Location in patent: Page/Page column 48
[4] Patent: WO2012/32014, 2012, A1. Location in patent: Page/Page column 94
[5] Patent: US2012/214782, 2012, A1. Location in patent: Page/Page column 40 |
| | 4-IODO-2-PYRIDONE Preparation Products And Raw materials |
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