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| | 5-Fluoro-2-methoxyphenylboronic acid Basic information |
| | 5-Fluoro-2-methoxyphenylboronic acid Chemical Properties |
| Melting point | 144-153 °C (lit.) | | Boiling point | 337.1±52.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | solubility | soluble in Methanol | | pka | 7.52±0.58(Predicted) | | form | Crystalline Powder | | color | White | | InChI | 1S/C7H8BFO3/c1-12-7-3-2-5(9)4-6(7)8(10)11/h2-4,10-11H,1H3 | | InChIKey | CCQKIRUMTHHPSX-UHFFFAOYSA-N | | SMILES | COc1ccc(F)cc1B(O)O | | CAS DataBase Reference | 179897-94-0(CAS DataBase Reference) |
| | 5-Fluoro-2-methoxyphenylboronic acid Usage And Synthesis |
| Chemical Properties | White to off-white powder | | Uses | 5-Fluoro-2-methoxyphenylboronic Acid is an important building blocks in organic syntheses. A reagent for Suzuki coupling reactions and copper catalyzed arylation reactions. A bacterial mutagen. | | Uses | Reactant for:• ;Suzuki couplings1,2• ;Copper catalyzed arylation3 | | Uses | suzuki reaction | | Synthesis | There are two main methods to synthesize 5-fluoro-2-methoxyphenylboronic acid: 1) Reacting with p-fluoroanisole and n-butyllithium solution dissolved in THF at -60 .
, then react with triisopropyl borate at -70 and then acidify with hydrochloric acid to obtain; 2) Use 2-bromo-4-fluoroanisole and n-butyllithium solution dissolved in THF first.
2) obtained by reacting 2-bromo-4-fluoroanisole with n-butyllithium solution dissolved in THF at -78 , then reacting with trimethyl borate at room temperature, then acidified with hydrochloric acid and washed with ammonium chloride solution. |
| | 5-Fluoro-2-methoxyphenylboronic acid Preparation Products And Raw materials |
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