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| | INNO-206 HCl salt/INNO206 HCl salt Basic information |
| Product Name: | INNO-206 HCl salt/INNO206 HCl salt | | Synonyms: | INNO-206 HCI;2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid [1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide monohydrochloride;INNO-206 monohydrochloride;INNO-206 HCL;Aldoxorubicin·HCl;INNO-206 hydrochloride;INNO-206 HCl salt/INNO206 HCl salt;MC-DOXHZN hydrochloride | | CAS: | 480998-12-7 | | MF: | C37H42N4O13.ClH | | MW: | 787.21 | | EINECS: | | | Product Categories: | | | Mol File: | 480998-12-7.mol |  |
| | INNO-206 HCl salt/INNO206 HCl salt Chemical Properties |
| storage temp. | Store at -20°C, sealed storage, away from moisture and light | | solubility | DMSO : 25 mg/mL (31.76 mM; Need ultrasonic)| | | form | A solid | | color | Brown to reddish brown | | Water Solubility | Water : 12.5 mg/mL (15.88 mM; ultrasonic and warming and heat to 60°C) |
| | INNO-206 HCl salt/INNO206 HCl salt Usage And Synthesis |
| Uses | MC-DOXHZN ((E/Z)-Aldoxorubicin) hydrochloride is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), with acid-sensitive properties[1]. | | IC 50 | Topoisomerase II; Daunorubicins/Doxorubicins | | References | [1] Sevim Rollas, et al. Hydrazone, Amide, Carbamate, Macromolecular and Other Prodrugs of Doxorubicin. The Open Drug Delivery Journal, 2008, 2, 77-85.
[2] Inoh K, et al. Doxorubicin-conjugated anti-midkine monoclonal antibody as a potential anti-tumor drug[J]. Japanese journal of clinical oncology, 2006, 36(4): 207-211. DOI:10.1093/jjco/hyl004 |
| | INNO-206 HCl salt/INNO206 HCl salt Preparation Products And Raw materials |
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