MnTBAP chloride NEW
| Price | $40 |
| Package | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-11-04 |
Product Details
| Product Name: MnTBAP chloride | CAS No.: 55266-18-7 |
| Supply Ability: 10g | Release date: 2025/11/04 |
Product Introduction
Bioactivity
| Name | MnTBAP chloride |
| Description | MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory effects through upregulation of BMPR-II and inhibition of NFκB signaling. mnTBAP chloride is a manganese porphyrin complex with antioxidant properties and has potential for use in the study of fibrotic responses in chronic kidney diseases (CKDs). |
| In vitro | Due to its superoxide dismutase mimetic property, 50 microM MnTBAP was found to attenuate the injury produced dose-dependently by exposure to various concentrations of paraquat for 4 h. MnTBAP also protected endothelial cells in a dose-dependent manner against paraquat. The protective effect of MnTBAP appears to be caused by its intracellular superoxide-scavenging activity because neither the zinc form nor CuZnSOD protected the cells against paraquat-induced injury.[1] |
| In vivo | Local administration of MnTBAP significantly and reduced carrageenan-induced paw oedema dose-dependently at all time points, which was related to its superoxide dismutase mimetic property. MnTBAP also caused a significant dose-dependent reduction in paw myeloperoxidase activity, as well as preventing histological injury. Immunohistochemical analyses for nitrotyrosine showed a positive staining in paw from carrageenan-treated rats.[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (4.57 mM), Sonication is recommended. DMSO : 90.0 mg/mL (102.4 mM), Sonication is recommended. 0.5 M NaOH : 18.0 mg/mL (20.5 mM), Sonication is recommended. 1M NaOH : 9.0 mg/mL (10.2 mM), when pH is adjusted to 8 with NaOH. Sonication is recommended. |
| Keywords | NF-κB | NFκB | NF-kB | NFkB | MnTBAP Chloride | Antioxidant |
| Inhibitors Related | Butylated hydroxytoluene | AFMK | Diethylmaleate | Propyl gallate | L-Tartaric acid | Glucosamine | Neohesperidin | Sulbutiamine | Lidocaine hydrochloride | L-Cystine | Indole-3-carbinol | Diallyl disulfide |
| Related Compound Libraries | NF-κB Signaling Compound Library | Bioactive Compound Library | HIF-1 Signaling Pathway Compound Library | Anti-Breast Cancer Compound Library | Hematonosis Compound Library | Antioxidant Compound Library | Anti-Fibrosis Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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