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1',3'-bis[1,2-dioleoyl-sn-glycero-3-phospho]-sn-glycerol (sodiuM salt)

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1',3'-bis[1,2-dioleoyl-sn-glycero-3-phospho]-sn-glycerol (sodiuM salt) Basic information
Product Name:1',3'-bis[1,2-dioleoyl-sn-glycero-3-phospho]-sn-glycerol (sodiuM salt)
Synonyms:1',3'-BIS[1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHO]-SN-GLYCEROL (SODIUM SALT);18:1 CARDIOLIPIN;18:1 Cardiolipin;1',3'-bis[1,2-dioleoyl-sn-glycero-3-phospho]-sn-glycerol (sodium salt);Diphosphatidylglycerol (18:1);Cardiolipin (18:1/18:1/18:1/18:1) (sodium salt);1',3'-bis[1,2-dioleoyl-sn-glycero-3-phospho]-glycerol (sodium salt)
CAS:115404-77-8
MF:C81H151NaO17P2
MW:1482.02
EINECS:
Product Categories:
Mol File:115404-77-8.mol
1',3'-bis[1,2-dioleoyl-sn-glycero-3-phospho]-sn-glycerol (sodiuM salt) Structure
1',3'-bis[1,2-dioleoyl-sn-glycero-3-phospho]-sn-glycerol (sodiuM salt) Chemical Properties
storage temp. -20°C
solubility Methanol: Soluble
form Solid
color White to off-white
InChIKeyFDXQAIKBMAOCEB-IGZBPXKBNA-N
Safety Information
WGK Germany WGK 3
Storage Class6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects
Hazard ClassificationsAcute Tox. 3 Inhalation
Acute Tox. 4 Oral
Aquatic Chronic 3
Carc. 2
Eye Irrit. 2
Repr. 2
Skin Irrit. 2
STOT RE 1
STOT SE 3
MSDS Information
1',3'-bis[1,2-dioleoyl-sn-glycero-3-phospho]-sn-glycerol (sodiuM salt) Usage And Synthesis
Uses1'',3''-bis[1,2-Dioleoyl-sn-glycero-3-phospho]-glycerol Sodium Salt is used as a pharmaceutical compound for inhibition of inflammation.
Biological ActivityCardiolipin (CL) plays a key role in coordinating energy metabolism in eukaryotes. Metabolic defect in the CL pathway is implicated in dilated cardiomyopathy. CL is essential for mitochondrial functions and apoptosis. Alternations in CL content and their acyl chain composition, contributes to mitochondrial dysfunction in various pathological conditions.', 'Cardiolipin is involved in the dynamic organization of membranes and in cell division. It modulates the proton uptake pathway. Cardiolipin plays a critical role in mitochondrial biogenesis, fusion and fission, respiration and protein import. It controls cell wall biogenesis, vacuole homeostasis, aging, cell cycle and apoptosis.', 'Cardiolipin participates in proton uptake pathway and also maintains the structure of enzymes involved. Cardiolipin maintains the mitochondrial function, membrane potential and structural support for the inner mitochondrial membrane and proteins in it. Concentration and composition changes of cardiolipin have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy.
References[1] ÁLVAREZ-BENEDICTO E, FARBIAK L, RAMÍREZ M M, et al. Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA)†[J]. Biomaterials Science, 2021, 2: 549-559. DOI: 10.1039/d1bm01454d
1',3'-bis[1,2-dioleoyl-sn-glycero-3-phospho]-sn-glycerol (sodiuM salt) Preparation Products And Raw materials
Tag:1',3'-bis[1,2-dioleoyl-sn-glycero-3-phospho]-sn-glycerol (sodiuM salt)(115404-77-8) Related Product Information
9-Octadecenoic acid (9Z)-, 1,1'-[(1R,13R)-4,7,10-trihydroxy-4,10-dioxido-1,13-bis[[(1-oxohexadecyl)oxy]methyl]-3,5,9,11-tetraoxa-4,10-diphosphatridecane-1,13-diyl] ester, sodium salt (1:2) 1',3'-bis[1,2-diMyristoyl-sn-glycero-3-phospho]-sn-glycerol (sodiuM salt) Hexadecanoic acid (R)-2-({3-[((R)-2,3-bis-hexadecanoyloxy-propoxy)-hydroxy-phosphoryloxy]-2-hydroxy-propoxy}-hydroxy-phosphoryloxy)-1-hexadecanoyloxymethyl-ethyl ester 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (sodiuM salt) Octadecanoic acid, 5,8,11-trihydroxy-5,11-dioxido-4,6,10,12-tetraoxa-5,11-diphosphapentadecane-1,2,14,15-tetrayl ester, disodium salt, [R-(R*,R*)]- (9CI)