|
|
| | dimethyl (tert-butoxycarbonyl)-L-aspartate Basic information |
| Product Name: | dimethyl (tert-butoxycarbonyl)-L-aspartate | | Synonyms: | L-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, dimethyl ester;dimethyl (tert-butoxycarbonyl)-L-aspartate;L-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1,4-dimethyl ester;(S)-dimethyl 2-(tert-butoxycarbonylamino)succinate;N-α-(t-Butoxycarbonyl)-L-aspartic acid α,β-dimethyl ester;Dimethyl (S)-2-(Boc-amino)succinate;N-Boc-L-aspartic acid dimethyl ester | | CAS: | 55747-84-7 | | MF: | C11H19NO6 | | MW: | 261.27 | | EINECS: | | | Product Categories: | | | Mol File: | 55747-84-7.mol |  |
| | dimethyl (tert-butoxycarbonyl)-L-aspartate Chemical Properties |
| Melting point | 64-65 °C | | Boiling point | 356.5±32.0 °C(Predicted) | | density | 1.136±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 10.36±0.46(Predicted) |
| | dimethyl (tert-butoxycarbonyl)-L-aspartate Usage And Synthesis |
| Synthesis | Step 1: Dimethyl (S)-2-aminosuccinate hydrochloride (5.0 g, 25.3 mmol) was dissolved in a solvent mixture of dichloromethane (50 mL) and water (25 mL) and sodium bicarbonate (4.25 g, 50.6 mmol) was added to the system. The reaction mixture was stirred for 4 hours and then the solvent was removed by rotary evaporator. The crude product was purified by recrystallization from n-heptane to give the target compound in white solid form (5.97 g, yield: 90%). | | References | [1] Patent: CN108148022, 2018, A. Location in patent: Paragraph 0187; 0188; 0189
[2] Acta Crystallographica Section C: Crystal Structure Communications, 2013, vol. 69, # 1, p. 82 - 86
[3] Patent: WO2013/114250, 2013, A1. Location in patent: Page/Page column 168
[4] Heterocycles, 1997, vol. 44, # 1, p. 213 - 225
[5] Tetrahedron Asymmetry, 2000, vol. 11, # 15, p. 3063 - 3068 |
| | dimethyl (tert-butoxycarbonyl)-L-aspartate Preparation Products And Raw materials |
|