1-(2-Bromoethyl)-4-fluorobenzene

1-(2-Bromoethyl)-4-fluorobenzene Suppliers list

Company Name:	Meryer (Shanghai) Chemical Technology Co., Ltd.
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Company Name:	TCI (Shanghai) Development Co., Ltd.
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1-(2-Bromoethyl)-4-fluorobenzene manufacturers

1-(2-Bromoethyl)-4-fluorobenzene Basic information

Product Name:	1-(2-Bromoethyl)-4-fluorobenzene
Synonyms:	1-FLUORO-4-(2-BROMOETHYL)BENZENE;1-BROMO-2-(4-FLUOROPHENYL)ETHANE;2-(4-FLUOROPHENYL)ETHYL BROMIDE;4-FLUORO-1-(2-BROMOETHYL)BENZENE;4-FLUOROPHENETHYL BROMIDE;1-(2-Bromoethyl)-4-fluoroBenzene,4-FluorophenethylBromide;1-Bromo-2-(4-fluorophenyl)ethane 97%;1-Bromo-2-(4-fluorophenyl)ethane97%
CAS:	332-42-3
MF:	C8H8BrF
MW:	203.05
EINECS:
Product Categories:	Fluorine series;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	332-42-3.mol

1-(2-Bromoethyl)-4-fluorobenzene Chemical Properties

Boiling point	100-104 °C15 mm Hg(lit.)
density	1.4498 g/mL at 25 °C(lit.)
refractive index	n20/D 1.534(lit.)
Fp	200 °F
storage temp.	Sealed in dry,Room Temperature
form	Liquid or Low Melting Solid
color	Clear colorless to light yellow or white to pale yellow
InChI	1S/C8H8BrF/c9-6-5-7-1-3-8(10)4-2-7/h1-4H,5-6H2
InChIKey	FLRUNCJXOVYWDH-UHFFFAOYSA-N
SMILES	Fc1ccc(CCBr)cc1
CAS DataBase Reference	332-42-3(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

1-(2-Bromoethyl)-4-fluorobenzene Usage And Synthesis

Chemical Properties	Clear slightly yellow liquid
Uses	An intermediate in the production of protein A mimetics, serotonin antagonists, and other CNS agents
Synthesis	7589-27-7 332-42-3 Preparative Example 1 Synthesis of 4-fluorophenethyl bromide: Triphenylphosphine (222 g) and N-bromosuccinimide (151 g) were sequentially added to a solution of 4-fluorophenylethanol (100 g) in dichloromethane (1 L) under cooling conditions in an ice bath and the reaction was carried out with continuous stirring for 1 hour. Upon completion of the reaction, the resulting solution was concentrated under reduced pressure and the precipitated crystals were subsequently filtered. The filtrate was further concentrated to afford the target product 4-fluorobromoethylbenzene (133 g) as a colorless oil (yield: 92%). The product was characterized by 1H-NMR (400 MHz, CDCl3): δ (ppm) 3.14 (2H, t, J = 8 Hz), 3.54 (2H, t, J = 8 Hz), 6.98-7.03 (2H, m), 7.15-7.18 (2H, m).
References	[1] Journal of Organic Chemistry, 2006, vol. 71, # 18, p. 7035 - 7044 [2] Tetrahedron Asymmetry, 2001, vol. 12, # 4, p. 585 - 596 [3] Patent: US2002/19531, 2002, A1 [4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 8, p. 2989 - 3002 [5] Patent: EP2508526, 2012, A1. Location in patent: Page/Page column 48

1-(2-Bromoethyl)-4-fluorobenzene Preparation Products And Raw materials

Raw materials

Tag:1-(2-Bromoethyl)-4-fluorobenzene(332-42-3) Related Product Information

4-Fluoro-3-(trifluoromethyl)phenacyl bromid Pentafluorophenacyl bromide 1-(2-Bromoethyl)-4-fluorobenzene (2-Bromoethyl)benzene 2-Bromo-4'-fluoroacetophenone 2-Bromo-2',4'-difluoroacetophenone 2-Bromo-1-(3,4-difluorophenyl)ethan-1-one alpha,alpha-Dibromo-4-fluoroacetophenone 3-Fluorophenethyl bromide 4-Fluoro-2-(trifluoromethyl)phenacyl bromide 1-(1-bromoethyl)-4-fluorobenzene 2-Bromo-3-(4-fluoro-3-methylphenyl)prop-1-ene 2-BROMO-2-PHENYL-1-(γ-FLUOROPHENYL)-ETHANONE 2-Bromo-3-(3,4-difluorophenyl)-1-propene 2-Bromo-3-(3-chloro-4-fluorophenyl)-1-propene 2-Bromo-3'-chloro-4'-fluoroacetophenone, 96% 1-(p-Fluorophenyl)-1,2-dibromoethane 2-Bromo-1-(4-fluorophenyl)-1-ethanone oxime