- p-Fluorophenacyl bromide
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- $200.00 / 1KG
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2025-09-25
- CAS:403-29-2
- Min. Order: 1KG
- Purity: 99%, 99.5% Sublimated
- Supply Ability: g-kg-tons, free sample is available
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| | 2-Bromo-4'-fluoroacetophenone Basic information |
| | 2-Bromo-4'-fluoroacetophenone Chemical Properties |
| Melting point | 47-49 °C(lit.) | | Boiling point | 150 °C12 mm Hg(lit.) | | density | 1.5728 (rough estimate) | | refractive index | 1.5450 (estimate) | | Fp | >230 °F | | storage temp. | Inert atmosphere,2-8°C | | solubility | Soluble in methanol. | | form | Powder | | color | White to brownish-yellow to light grey | | Sensitive | Lachrymatory | | BRN | 637863 | | InChI | 1S/C8H6BrFO/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2 | | InChIKey | ZJFWCELATJMDNO-UHFFFAOYSA-N | | SMILES | Fc1ccc(cc1)C(=O)CBr | | CAS DataBase Reference | 403-29-2(CAS DataBase Reference) | | NIST Chemistry Reference | Acetophenone, 2-bromo-4'-fluoro-(403-29-2) |
| Hazard Codes | C,Xi | | Risk Statements | 34 | | Safety Statements | 26-36/37/39-45-27 | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 3 | | Hazard Note | Corrosive/Lachrymatory/Keep Cold | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29147000 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Skin Corr. 1B |
| | 2-Bromo-4'-fluoroacetophenone Usage And Synthesis |
| Chemical Properties | beige to light grey-green cryst. powder or flakes | | Uses | 2-Bromo-4’fluoroacetophenone is a intermediate in the synthetic preparation of competitive inhibitors of aromatase. | | Uses | 2-Bromo-4'-fluoroacetophenone is used as an organic chemical synthesis intermediate. | | Synthesis | General procedure for the synthesis of 2-bromo-4'-fluoroacetophenone using 4-fluoroacetophenone as starting material: general method: oxone (1.352 g, 2.2 mmol) was added to a well-stirred methanol (10 ml) solution of 4-fluoroacetophenone (2 mmol) and NH4Br (0.215 g, 2.2 mmol), and the reaction mixture was stirred at room temperature (or refluxed at temperature reaction). The reaction progress was monitored by TLC. Upon completion of the reaction, the reaction mixture was quenched with aqueous sodium thiosulfate, followed by extraction with ethyl acetate (3 x 25 ml). The organic layers were combined, washed with water, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to remove the solvent to give the crude product. The crude product was further purified by silica gel column chromatography (200-300 mesh) to give pure 2-bromo-4'-fluoroacetophenone. All products were structurally confirmed by 1H NMR and mass spectrometry data. | | References | [1] Farmaco, 1993, vol. 48, # 6, p. 857 - 869
[2] Synthesis, 2008, # 2, p. 253 - 266
[3] Tetrahedron Letters, 2012, vol. 53, # 2, p. 191 - 195
[4] Tetrahedron, 1992, vol. 48, # 1, p. 67 - 78
[5] Bulletin of the Chemical Society of Japan, 1999, vol. 72, # 6, p. 1327 - 1334 |
| | 2-Bromo-4'-fluoroacetophenone Preparation Products And Raw materials |
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