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MKC3946

MKC3946 Suppliers list

Company Name:	ATK CHEMICAL COMPANY LIMITED
Tel:	+undefined-21-51877795
Email:	ivan@atkchemical.com
Products Intro:	Product Name:MKC-3946 CAS:1093119-54-0 Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G

Company Name:	BOC Sciences
Tel:	16314854226; +16314854226
Email:	inquiry@bocsci.com
Products Intro:	Product Name:MKC-3946 CAS:1093119-54-0 Purity:>98% Package:300 mg Remarks:Please reach out to us for more information about custom solutions.

Company Name:	InvivoChem
Tel:	+1-708-310-1919 +1-13798911105
Email:	sales@invivochem.cn
Products Intro:	Product Name:MKC3946 CAS:1093119-54-0 Purity:98% Package:5mg Remarks:V3985

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354;
Email:	support@targetmol.com
Products Intro:	Product Name:MKC3946 CAS:1093119-54-0 Purity:99.65% Package:1mg;61USD\|5mg;173USD\|10mg;279USD

Company Name:	Wuhan Topule Biopharmaceutical Co., Ltd
Tel:	+8618327326525
Email:	masar@topule.com
Products Intro:	Product Name:MKC3946 CAS:1093119-54-0 Purity:98% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing

MKC3946 manufacturers

MKC3946
$48.00
2026-06-02
CAS:1093119-54-0
Purity: 99.97%
Supply Ability: 10g

MKC3946 Basic information

Product Name:	MKC3946
Synonyms:	MKC3946;MKC-3946;MKC 3946;MKC3946;1-Naphthalenecarboxaldehyde, 2-hydroxy-6-[5-[(4-methyl-1-piperazinyl)carbonyl]-2-thienyl]-;2-Hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde;Inositol requiring enzyme 1,inhibit,IRE1,MKC3946,Inhibitor,MKC 3946,MKC-3946;MKC3946, 10 mM in DMSO;IRE1α Inhibitor, MKC-3946;MKC-3946 ，S8286
CAS:	1093119-54-0
MF:	C21H20N2O3S
MW:	380.46
EINECS:
Product Categories:
Mol File:	1093119-54-0.mol

MKC3946 Chemical Properties

Boiling point	591.6±50.0 °C(Predicted)
density	1.337±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO:20.0(Max Conc. mg/mL);52.57(Max Conc. mM)
form	A crystalline solid
pka	8.18±0.50(Predicted)
color	White to yellow
InChI	1S/C21H20N2O3S/c1-22-8-10-23(11-9-22)21(26)20-7-6-19(27-20)15-2-4-16-14(12-15)3-5-18(25)17(16)13-24/h2-7,12-13,25H,8-11H2,1H3
InChIKey	IVQVBMWPWPTSNO-UHFFFAOYSA-N
SMILES	[s]1c(ccc1C(=O)N4CCN(CC4)C)c2cc3c(c(c(cc3)O)C=O)cc2

Safety Information

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

MSDS Information

MKC3946 Usage And Synthesis

Uses

MKC3946 is a potent IRE1α inhibitor, used for cancer research.

Biological Activity

MKC3946 is a soluble inhibitor of the IRE1α endoribonuclease domain, causing moderate growth inhibition in multiple myeloma cell lines without toxic effects on normal monocytes.

in vivo

In an in vivo model of endoplasmic reticulum stress, MKC-3946 inhibits cleavage of XBP1 and significantly inhibits myeloma cell growth.

target

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Target	Value
IRE1α endoribonuclease ()
References	[1] Sun H, et al. Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia. Oncotarget. 2016 Apr 5;7(14):18736-49 DOI:10.18632/oncotarget.7702 [2] Zhang L, et al. IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis. BMC Cell Biol. 2014 Jul 10;15:29. DOI:10.1186/1471-2121-15-29 [3] Mimura N, et al. Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma. Blood. 2012 Jun 14;119(24):5772-81 DOI:10.1182/blood-2011-07-366633

MKC3946 Preparation Products And Raw materials

Tag:MKC3946(1093119-54-0) Related Product Information

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide GSK2656157 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine MKC8866 ISRIB MK-8998 MK-4101 MK8745 MK-3903 mk-1064 MK 0557 MK-0812 (Succinate) MKC9989

MKC3946

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