CHOLIC-2,2,4,4-D4 ACID manufacturers
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| | CHOLIC-2,2,4,4-D4 ACID Basic information |
| Product Name: | CHOLIC-2,2,4,4-D4 ACID | | Synonyms: | Cholic-d4 Acid;5β-cholanic acid-3α,7α,12α-triol-2,2,4,4-d4;CHOLIC ACID (2,2,4,4-D4, 98%) 100 UG/ML IN METHANOL;Cholic Acid -[d4] (Solution);Cholic Acid-d4 MaxSpec? Standard;2H4]-Cholic Acid;CHOLICACID(2,2,4,4-D4) IN METHANOL;Cholic acid-D4 | | CAS: | 116380-66-6 | | MF: | C24H36D4O5 | | MW: | 412.6 | | EINECS: | | | Product Categories: | Steroids & Hormones - 13C & 2H | | Mol File: | 116380-66-6.mol |  |
| | CHOLIC-2,2,4,4-D4 ACID Chemical Properties |
| Melting point | 200-201°C (lit.) | | Boiling point | 583.876±50.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.185±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml | | pka | 4.758±0.10(predicted) | | form | Solid | | color | White to Off-White | | InChIKey | BHQCQFFYRZLCQQ-XJNZYMKVNA-N | | SMILES | [2H]C1([2H])C[C@]2(C)[C@H]3C[C@H](O)[C@]4(C)[C@H](CC[C@H]4[C@@H]3[C@H](O)C[C@@H]2C([2H])([2H])[C@@H]1O)[C@H](C)CCC(O)=O | | CAS Number Unlabeled | 81-25-4 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | CHOLIC-2,2,4,4-D4 ACID Usage And Synthesis |
| Description | Cholic acid-d4 is intended for use as an internal standard for the quantification of cholic acid by GC- or LC-MS. Cholic acid is a primary bile acid. It is formed from cholesterol via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. Cholic acid is conjugated to glycine or taurine by bile acid-CoA:amino acid N-acyltransferase (BAAT) to produce glycocholic acid (GCA; ) and taurocholic acid (TCA; ), respectively, in the liver, and is transformed into the secondary bile acid deoxycholic acid (DCA; ) by intestinal microbiota. It induces C. difficile colony formation in an agar dilution assay when used at a concentration of 0.1% w/v. Dietary administration of cholic acid (0.4% w/w) increases serum cholesterol levels, biliary phospholipid secretion, and fecal DCA levels in rats. | | Uses | Cholic Acid-d4 is a labelled analog of Cholic acid (C432600) which is a choleretic produced by, and isolated from liver cells. | | Definition | ChEBI: Cholic acid-2,2,4,4-d4 is a bile acid. | | References | [1] TANJA M ARENAC Momir M. Bile Acid Synthesis: From Nature to the Chemical Modification and Synthesis and Their Applications as Drugs and Nutrients.[J]. Frontiers in Pharmacology, 2018: 939. DOI: 10.3389/fphar.2018.00939
[2] MARY C. HUNT Stefan E H A Marina I Siponen. The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism[J]. Biochimica et biophysica acta. Molecular basis of disease, 2012, 1822 9: Pages 1397-1410. DOI: 10.1016/j.bbadis.2012.03.009
[3] CHRISTOPHER STALEY. Interaction of gut microbiota with bile acid metabolism and its influence on disease states[J]. Applied Microbiology and Biotechnology, 2016, 101 1: 47-64. DOI: 10.1007/s00253-016-8006-6
[4] JOSEPH A SORG A L S. Bile salts and glycine as cogerminants for Clostridium difficile spores.[J]. Journal of Bacteriology, 2008: 2505-2512. DOI: 10.1128/jb.01765-07
[5] K UCHIDA N T Y Nomura. Effects of cholic acid, chenodeoxycholic acid, and their related bile acids on cholesterol, phospholipid, and bile acid levels in serum, liver, bile, and feces of rats.[J]. Journal of biochemistry, 1980, 87 1: 187-194. DOI: 10.1093/oxfordjournals.jbchem.a132724
[6] PENGXIANG QU. DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates.[J]. Cell metabolism, 2023, 35 5: 742-757.e10. DOI: 10.1016/j.cmet.2023.03.013 |
| | CHOLIC-2,2,4,4-D4 ACID Preparation Products And Raw materials |
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