Bromoacetamido-PEG8-t-butyl ester manufacturers
- BrCH2CONH-PEG8-COOtBu
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2025-06-07
- CAS:2055041-16-0
- Min. Order: 500mg
- Purity: >98.00%
- Supply Ability: 500mg
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| | Bromoacetamido-PEG8-t-butyl ester Basic information |
| Product Name: | Bromoacetamido-PEG8-t-butyl ester | | Synonyms: | Bromoacetamido-PEG8-t-butyl ester;Bromoacetamido-PEG8-Boc;4,7,10,13,16,19,22,25-Octaoxa-28-azatriacontanoic acid, 30-bromo-29-oxo-, 1,1-dimethylethyl ester | | CAS: | 2055041-16-0 | | MF: | C25H48BrNO11 | | MW: | 618.55 | | EINECS: | | | Product Categories: | | | Mol File: | 2055041-16-0.mol |  |
| | Bromoacetamido-PEG8-t-butyl ester Chemical Properties |
| Boiling point | 657.2±55.0 °C(Predicted) | | density | 1.201±0.06 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 13.20±0.46(Predicted) |
| | Bromoacetamido-PEG8-t-butyl ester Usage And Synthesis |
| Description | Bromoacetamido-PEG8-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | Bromoacetamido-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Bromoacetamido-PEG8-t-butyl ester Preparation Products And Raw materials |
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