Bromoacetamido-PEG3-t-Butyl Ester manufacturers
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| | Bromoacetamido-PEG3-t-Butyl Ester Basic information |
| Product Name: | Bromoacetamido-PEG3-t-Butyl Ester | | Synonyms: | BrCH2CONH-PEG3-COOtBu;Bromoacetamido-PEG3-t-Butyl Ester;Bromoacetamido-PEG3-C2-Boc;tert-Butyl 1-bromo-2-oxo-6,9,12-trioxa-3-azapentadecan-15-oate;tert-butyl 1-bromo-2-oxo-6,9,13-trioxa-3-azahexadecan-16-oate;4,7,10-Trioxa-13-azapentadecanoic acid, 15-bromo-14-oxo-, 1,1-dimethylethyl ester | | CAS: | 1807537-33-2 | | MF: | C15H28BrNO6 | | MW: | 398.29 | | EINECS: | | | Product Categories: | | | Mol File: | 1807537-33-2.mol |  |
| | Bromoacetamido-PEG3-t-Butyl Ester Chemical Properties |
| Boiling point | 507.6±50.0 °C(Predicted) | | density | 1.252±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | pka | 13.20±0.46(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | Bromoacetamido-PEG3-t-Butyl Ester Usage And Synthesis |
| Description | Bromoacetamido-PEG3-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | Bromoacetamido-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Bromoacetamido-PEG3-t-Butyl Ester Preparation Products And Raw materials |
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