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| | N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester) Basic information |
| Product Name: | N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester) | | Synonyms: | N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester);N-(Amino-PEG4)-N-bis(PEG4-Boc);4,7,10,13,19,22,25,28-Octaoxa-16-azahentriacontanedioic acid, 16-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)-, 1,31-bis(1,1-dimethylethyl) ester;HUN 53978;Di-tert-butyl 16-(14-amino-3,6,9,12-tetraoxatetradecyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontanedioate;N-(Amino-PEG4)-N-bis(PEG4-tert-butyl Ester) | | CAS: | 2093153-97-8 | | MF: | C40H80N2O16 | | MW: | 845.07 | | EINECS: | | | Product Categories: | | | Mol File: | 2093153-97-8.mol |  |
| | N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester) Chemical Properties |
| Boiling point | 769.1±55.0 °C(Predicted) | | density | 1.079±0.06 g/cm3(Predicted) | | pka | 8.74±0.10(Predicted) |
| | N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester) Usage And Synthesis |
| Description | N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester) is a branched PEG reagent containing an amino group with two t-butyl esters. The amino groups is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | N-(Amino-PEG4)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester) Preparation Products And Raw materials |
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