N-(Amino-PEG3)-N-bis(PEG4-Boc) manufacturers
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| | N-(Amino-PEG3)-N-bis(PEG4-Boc) Basic information |
| Product Name: | N-(Amino-PEG3)-N-bis(PEG4-Boc) | | Synonyms: | N-(Amino-PEG3)-N-bis(PEG4-Boc);N-(Amino-PEG3)-N-bis(PEG4-t-butyl ester);tert-butyl 3-[2-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl-[2-[2-[2-[2-(3-tert-butoxy-3-oxo-propoxy)ethoxy]ethoxy]ethoxy]ethyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate;4,7,10,13,19,22,25,28-Octaoxa-16-azahentriacontanedioic acid, 16-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]-, 1,31-bis(1,1-dimethylethyl) ester;Di-tert-butyl 16-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)-4,7,10,13,19,22,25,28-octaoxa-16-azahentriacontanedioate | | CAS: | 2353409-57-9 | | MF: | C38H76N2O15 | | MW: | 801.01 | | EINECS: | | | Product Categories: | | | Mol File: | 2353409-57-9.mol |  |
| | N-(Amino-PEG3)-N-bis(PEG4-Boc) Chemical Properties |
| Boiling point | 743.7±55.0 °C(Predicted) | | density | 1.076±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, protect from light | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 8.74±0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | N-(Amino-PEG3)-N-bis(PEG4-Boc) Usage And Synthesis |
| Description | N-(Amino-PEG3)-N-bis(PEG4-t-butyl ester) is a PEG linker that can easily react with activated NHS esters or carboxylic acid in the presence of EDC or HATU. The t-butyl group can be deprotected under acidic conditions. | | Uses | N-(Amino-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-(Amino-PEG3)-N-bis(PEG4-Boc) Preparation Products And Raw materials |
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