- 4-Bromophenetole
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- $9.90 / 1KG
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2025-12-11
- CAS:588-96-5
- Min. Order: 100KG
- Purity: 99%
- Supply Ability: 10 tons
- 4-Bromophenetole
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- $7.00 / 1kg
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2025-05-26
- CAS:588-96-5
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 10000
- 4-Bromophenetole
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- $10.00 / 1Kg/Bag
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2021-10-30
- CAS:588-96-5
- Min. Order: 1Kg/Bag
- Purity: 99%
- Supply Ability: 20 Tons
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| | 4-Bromophenetole Basic information |
| | 4-Bromophenetole Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 24/25 | | WGK Germany | 3 | | Hazard Note | Irritant | | TSCA | Yes | | HS Code | 29093090 |
| | 4-Bromophenetole Usage And Synthesis |
| Chemical Properties | CLEAR COLOURLESS TO YELLOWISH LIQUID | | Uses | 4-Bromophenetole is a non-irritant used to verify ocular irritability tests. | | Synthesis | Step 1: Synthesis of 1-bromo-4-ethoxybenzene: Potassium carbonate (118 g) was added to a solution of 4-bromophenol (50 g) in acetone (250 mL) at room temperature and stirred for 30 min. Subsequently, iodoethane (67.6 g) was added slowly and dropwise. The reaction mixture was heated to reflux for 10 hours and the progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was filtered and acetone was removed using a rotary evaporator. The residue was dissolved in ethyl acetate, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate and concentrated. Purification by silica gel column chromatography with ethyl acetate and hexane (1:7) as eluents afforded 4-bromophenetole as a colorless liquid (57 g, 98.27% yield).1H NMR (CDCl3, 300 MHz): δ 7.35 (d, J = 8.7 Hz, 2H), 6.76 (d, J = 8.7 Hz, 2H), 3.99 (q, J = 6.9 Hz, 2H), 1.40 (t, J = 6.9 Hz, 3H). | | References | [1] Patent: WO2012/25857, 2012, A1. Location in patent: Page/Page column 57-58
[2] Patent: US2010/331307, 2010, A1. Location in patent: Page/Page column 18
[3] Journal of the Korean Chemical Society, 2012, vol. 56, # 6, p. 706 - 711
[4] Journal of the American Chemical Society, 1931, vol. 53, p. 1408,1409
[5] Molecular Crystals and Liquid Crystals, 2004, vol. 411, p. 93/[1135]-102/[1144] |
| | 4-Bromophenetole Preparation Products And Raw materials |
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