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Methyl homoveratrate manufacturers
- METHYL HOMOVERATRATE
-
- $3.00
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2020-02-06
- CAS:15964-79-1
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 100KG
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| | Methyl homoveratrate Basic information |
| Product Name: | Methyl homoveratrate | | Synonyms: | METHYL 3,4-DIMETHOXYPHENYL ACETATE;VERATRYLACETIC ACID METHYL ESTER;Acetic acid, (3,4-dimethoxyphenyl)-, methyl ester;Homovanillic acid di-methyl derivative;Homoveratric acid, methyl ester;Methyl ester of 3,4-Dimethoxyphenylacetic acid;Phenylacetic acid, 3,4-dimethoxy, methyl ester;2-(3,4-Dimethoxyphenyl)acetic acid methyl ester | | CAS: | 15964-79-1 | | MF: | C11H14O4 | | MW: | 210.23 | | EINECS: | 240-100-3 | | Product Categories: | Catechol Derivatives;Aromatic Esters | | Mol File: | 15964-79-1.mol |  |
| | Methyl homoveratrate Chemical Properties |
| Boiling point | 175℃ (15 Torr) | | density | 1.105±0.06 g/cm3 (20 ºC 760 Torr) | | refractive index | 1.5253 (23℃) | | Fp | 121.6±23.2℃ | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Oil | | color | Colourless | | EPA Substance Registry System | Benzeneacetic acid, 3,4-dimethoxy-, methyl ester (15964-79-1) |
| | Methyl homoveratrate Usage And Synthesis |
| Uses | Methyl Homoveratrate can be used as entry inhibitors against H5N1. | | Synthesis | General procedure for the synthesis of methyl 3,4-dimethoxyphenylacetate from methanol and 3,4-dimethoxyphenylacetic acid: 3,4-dimethoxyphenylacetic acid (25.0 g, 127.4 mmol) was dissolved in methanol (100 mL) in a 500 mL round-bottomed flask and a catalytic amount of sulfuric acid (about 10 drops) was added. The reaction mixture was stirred overnight under reflux conditions. After completion of the reaction, it was cooled to room temperature and methanol was removed by distillation under reduced pressure at 40 °C. The crude product was dissolved in dichloromethane (250 mL), washed sequentially with water (5 x 20 mL) and saturated saline (20 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give methyl 3,4-dimethoxyphenylacetate (25.77 g, 96% yield) as an orange oil. Molecular weight: 210.23; yield: 96%; Rf value: 0.25 (cyclohexane:ethyl acetate=3:1). 1H-NMR (CDCl3, δ): 3.56 (s, 2H, CH2), 3.70 (s, 3H, CH3), 3.87 (s, 3H, OCH3), 3.88 (s, 3H, OCH3), 6.82-6.83 (m , 3H, ArH).13C-NMR (CDCl3, δ): 40.6, 51.9, 55.8 (2 × C), 111.2, 112.4, 121.4, 126.4, 148.2, 148.9, 172.2.MS-ESI m/z (% relative abundance): 233.2 ([M+Na]+, 3), 151.1 ( 100). | | References | [1] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 1, p. 85 - 90
[2] Tetrahedron, 2007, vol. 63, # 46, p. 11377 - 11385
[3] Tetrahedron, 2013, vol. 69, # 42, p. 8914 - 8920
[4] Patent: US2012/214837, 2012, A1. Location in patent: Page/Page column 23-24
[5] Journal of Organic Chemistry, 2003, vol. 68, # 3, p. 1165 - 1167 |
| | Methyl homoveratrate Preparation Products And Raw materials |
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