| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
- Homovanillic acid
-
-
2023-02-24
- CAS:306-08-1
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
|
| | Homovanillic acid Basic information |
| | Homovanillic acid Chemical Properties |
| Melting point | 142-145 °C(lit.) | | Boiling point | 235.56°C (rough estimate) | | density | 1.1634 (rough estimate) | | refractive index | 1.4209 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | pka | 4.39±0.10(Predicted) | | form | Crystalline Powder | | color | White to beige | | Water Solubility | soluble | | Merck | 14,4740 | | BRN | 2213447 | | Stability: | Hygroscopic | | Major Application | pharmaceutical | | InChI | 1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) | | InChIKey | QRMZSPFSDQBLIX-UHFFFAOYSA-N | | SMILES | COc1cc(CC(O)=O)ccc1O | | LogP | 0.330 | | CAS DataBase Reference | 306-08-1(CAS DataBase Reference) | | NIST Chemistry Reference | Benzeneacetic acid, 4-hydroxy-3-methoxy-(306-08-1) | | EPA Substance Registry System | Homovanillic acid (306-08-1) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | F | 10-23 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29189900 | | Storage Class | 11 - Combustible Solids |
| | Homovanillic acid Usage And Synthesis |
| Description | Homovanillic acid (HVA) is a dopamine metabolite. It is formed via deamination of dopamine by monoamine oxidase (MAO) to produce 3,4-dihydroxyphenylacetic acid (DOPAC; ) followed by DOPAC metabolism by catechol-O-methyltransferase (COMT). HVA undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer that displays excitation/emission maxima of 312/420 nm, respectively. It has been used to quantify hydrogen peroxide production in macrophages and neutrophils. | | Chemical Properties | white to beige crystalline powder | | Uses | A neuroendocrine tumor marker. Dihydroxyphenylacetic Acid (DOPAC) metabolite. | | Uses | Fluorimetric reagent and major catecholamine metaboliteHomovanillic acid is used as a reagent in the determination of oxidative enzymes. It is associated with dopamine levels in the brain. Its presence supports a diagnosis of neuroblastoma and malignant pheochromocytoma. | | Definition | ChEBI: A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite. | | Biological Activity | Fluorimetric reagent and major catecholamine metabolite. Used for fluorimetric determination of oxidative enzymes including glucose oxidase. | | storage | +4°C | | References | [1] MIKKO KENMKI. Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice[J]. Journal of Neurochemistry, 2010, 114 6: 1745-1755. DOI: 10.1111/j.1471-4159.2010.06889.x
[2] WALTER RUCH Marco B Philip H Cooper. Assay of H2O2 production by macrophages and neutrophils with homovanillic acid and horse-radish peroxidase[J]. Journal of immunological methods, 1983, 63 3: Pages 347-357. DOI: 10.1016/s0022-1759(83)80008-8 |
| | Homovanillic acid Preparation Products And Raw materials |
|