N-[2,4-dimethyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-[(pyridin-2-yl)methoxy]benzamide

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N-[2,4-dimethyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-[(pyridin-2-yl)methoxy]benzamide manufacturers

  • AZD8542
  • AZD8542 pictures
  • $163.00
  • 2026-07-27
  • CAS:1126366-36-6
  • Purity: 99.96%
  • Supply Ability: 10g
N-[2,4-dimethyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-[(pyridin-2-yl)methoxy]benzamide Basic information
Product Name:N-[2,4-dimethyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-[(pyridin-2-yl)methoxy]benzamide
Synonyms:N-[2,4-dimethyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-[(pyridin-2-yl)methoxy]benzamide;AZD 8542;AZD-8542;Benzamide, N-[2,4-dimethyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-(2-pyridinylmethoxy)-;AZD8542
CAS:1126366-36-6
MF:C25H24N4O2
MW:412.48
EINECS:682-628-0
Product Categories:
Mol File:1126366-36-6.mol
N-[2,4-dimethyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-[(pyridin-2-yl)methoxy]benzamide Structure
N-[2,4-dimethyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-[(pyridin-2-yl)methoxy]benzamide Chemical Properties
Boiling point 572.5±50.0 °C(Predicted)
density 1.18±0.1 g/cm3(Predicted)
pka13.32±0.70(Predicted)
Safety Information
MSDS Information
N-[2,4-dimethyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-[(pyridin-2-yl)methoxy]benzamide Usage And Synthesis
DescriptionAZD8542 is an antagonist of Smoothened (SMO), with potential as an oncology therapeutic. It is a novel Hedgehog (Hh) pathway antagonist on tumor progression with an emphasis on the role of the stroma compartment.
UsesAZD8542 is an antagonist of Smoothened (SMO), playing an important role in oncology. AZD8542 is a Hedgehog (Hh) pathway antagonist on tumor progression with an emphasis on the role of the stroma compartment[1][2].
References[1] Rosa F. Hwang, INHIBITION OF THE HEDGEHOG PATHWAY TARGETS THE TUMOR-ASSOCIATED STROMA IN PANCREATIC CANCER. Mol Cancer Res. 2012 Sep; 10(9): 1147–1157.
[2] Dakin Leslie, et al. Preparation of amide compounds containing heterocycle moiety as hedgehog pathway inhibitors. World Intellectual Property Organization, WO2009027746 A1
N-[2,4-dimethyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-[(pyridin-2-yl)methoxy]benzamide Preparation Products And Raw materials
Tag:N-[2,4-dimethyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-[(pyridin-2-yl)methoxy]benzamide(1126366-36-6) Related Product Information
N-[2,4-dimethyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-[(pyridin-2-yl)methoxy]benzamide Benzamide, N-[5-(1H-imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)-, hydrochloride (1:2) Hedgehog IN-2 N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide AZ 12080282 Dihydrochloride Benzamide, N-[2-methyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-(2-pyridinylmethoxy)-