N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide

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N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide manufacturers

  • AZD7254
  • AZD7254 pictures
  • $1980.00
  • 2026-05-11
  • CAS:1126366-28-6
  • Purity:
  • Supply Ability: 10g
N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide Basic information
Product Name:N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide
Synonyms:N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide;AZD7254;Benzamide, N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-(2-pyridinylmethoxy)-
CAS:1126366-28-6
MF:C24H22N4O2
MW:398.46
EINECS:682-708-5
Product Categories:
Mol File:1126366-28-6.mol
N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide Structure
N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide Chemical Properties
Boiling point 577.5±50.0 °C(Predicted)
density 1.262±0.06 g/cm3(Predicted)
pka13.33±0.31(Predicted)
Safety Information
MSDS Information
N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide Usage And Synthesis
UsesAZD7254 is an orally active Smoothened (SMO) inhibitor with an EC50 of 1.0 nM against sonic Hh protein (shh)[1].
in vivo

AZD7254 (40 mg/kg; p.o.; twice daily for 10 days) exhibits 42% tumor growth inhibition in an HT29-MEF (murine embryonic fibroblast) co-implant xenograft model[1].

References[1] Yang B, et al. Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254). Bioorg M DOI:10.1016/j.bmc.2019.115227
N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide Preparation Products And Raw materials
Tag:N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide(1126366-28-6) Related Product Information
N-[2,4-dimethyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-[(pyridin-2-yl)methoxy]benzamide Benzamide, N-[5-(1H-imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)-, hydrochloride (1:2) Hedgehog IN-2 N-[5-(1H-imidazol-2-yl)-2,4-dimethylphenyl]-4-[(pyridin-2-yl)methoxy]benzamide AZ 12080282 Dihydrochloride Benzamide, N-[2-methyl-5-(1-methyl-1H-imidazol-4-yl)phenyl]-4-(2-pyridinylmethoxy)-