K-11777 manufacturers
- K777
-
- $78.00
-
2026-08-15
- CAS:233277-99-1
- Purity: 99.14%
- Supply Ability: 10g
|
| | K-11777 Basic information |
| Product Name: | K-11777 | | Synonyms: | K-11777;4-methyl-N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide;1-Piperazinecarboxamide, 4-methyl-N-[(1S)-2-oxo-2-[[(1S)-1-(2-phenylethyl)-3-(phenylsulfonyl)-2-propen-1-yl]amino]-1-(phenylmethyl)ethyl]-;4-Methyl-N-((S)-1-oxo-3-phenyl-1-(((S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide;K777, 10 mM in DMSO;4-Methyl-N-((S)-1-oxo-3-phenyl-1-(((S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide , K777;K-177 | | CAS: | 233277-99-1 | | MF: | C32H38N4O4S | | MW: | 574.73 | | EINECS: | | | Product Categories: | | | Mol File: | 233277-99-1.mol |  |
| | K-11777 Chemical Properties |
| Boiling point | 861.0±65.0 °C(Predicted) | | density | 1.217±0.06 g/cm3(Predicted) | | solubility | DMSO: soluble | | form | A solid | | pka | 12.48±0.20(Predicted) | | color | White to off-white | | SMILES | CN1CCN(C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCC3=CC=CC=C3)/C=C/S(C4=CC=CC=C4)(=O)=O)=O)=O)CC1 |
| | K-11777 Usage And Synthesis |
| Uses | K777 Hydrochloride-d8 is the labelled analogue of K777 Hydrochloride (K165805). It acts as a cathespin B inhibitor which may be useful in the therapeutic treatment of Chagas’ disease. | | in vivo | K777 (K11777; 35-105 mg/kg; oral administration; twice a day; for 10 days; C57BL/6 IFN-γR-KO mice) treatment rescues mice from otherwise lethal infections[4] . | Animal Model: | C57BL/6 IFN-γR-KO mice (6-8 weeks of age) injected with Cryptosporidium parvum[4] | | Dosage: | 35 mg/kg, 70 mg/kg, and 105 mg/kg | | Administration: | Oral administration; twice a day; for 10 days | | Result: | Rescued mice from otherwise lethal infections. |
| | IC 50 | CYP3; EBOV; MARV; CCR4; Trypanosoma |
| | K-11777 Preparation Products And Raw materials |
|