- H-Sar-OMe·HCl
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- $0.00 / 1kg
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2026-01-26
- CAS:13515-93-0
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
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| | Sarcosine methyl ester hydrochloride Basic information |
| | Sarcosine methyl ester hydrochloride Chemical Properties |
| Melting point | 117-119 °C(lit.) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Crystals or Crystalline Powder | | color | White to beige | | Water Solubility | Soluble in water. | | Sensitive | Hygroscopic | | BRN | 3677128 | | Major Application | peptide synthesis | | InChI | InChI=1S/C4H9NO2.ClH/c1-5-3-4(6)7-2;/h5H,3H2,1-2H3;1H | | InChIKey | HQZMRJBVCVYVQA-UHFFFAOYSA-N | | SMILES | C(=O)(OC)CNC.Cl | | CAS DataBase Reference | 13515-93-0(CAS DataBase Reference) | | EPA Substance Registry System | Glycine, N-methyl-, methyl ester, hydrochloride (13515-93-0) |
| | Sarcosine methyl ester hydrochloride Usage And Synthesis |
| Chemical Properties | White to beige crystals or crystalline powder | | Uses | It can react with formic acid to get N-formyl-N-methyl-glycine methyl ester in the presence of HCO2Na at ambient temperature. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | General procedure for the synthesis of methyl sarcosinate hydrochloride from methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate: To a stirring solution of methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate (1 mmol) in dichloromethane (2 mL) was slowly added a solution of 3.3 M HCl in dioxane (5 mL) at 0 °C. The temperature of the reaction mixture was gradually increased to 20 °C and stirring was continued at this temperature for 1 hour. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting residue was placed in anhydrous ether and stirred to promote the formation of crystalline products. For less crystalline or hygroscopic products, the residue can be dissolved in dry chloroform, followed by evaporation of the solvent and drying of the product in a vacuum desiccator using P4O10 or KOH as the desiccant. A portion of the product may be purified by silica gel column chromatography using eluent mixture B or by gel filtration through biogel P2 or Fractogel TCK HW 40, followed by lyophilization to obtain a pure product. | | References | [1] Tetrahedron, 2012, vol. 68, # 35, p. 7070 - 7076 |
| | Sarcosine methyl ester hydrochloride Preparation Products And Raw materials |
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