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| | 3-Amino-4-methylbenzoic acid Basic information | | Uses |
| | 3-Amino-4-methylbenzoic acid Chemical Properties |
| Melting point | 164-168 °C (lit.) | | Boiling point | 273.17°C (rough estimate) | | density | 1.2023 (rough estimate) | | refractive index | 1.5810 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 4.61±0.10(Predicted) | | form | Crystalline Powder | | color | Pink to grayish | | Water Solubility | Very soluble in water. | | BRN | 2082449 | | Stability: | Hygroscopic | | Major Application | peptide synthesis | | InChI | 1S/C8H9NO2/c1-5-2-3-6(8(10)11)4-7(5)9/h2-4H,9H2,1H3,(H,10,11) | | InChIKey | XKFIFYROMAAUDL-UHFFFAOYSA-N | | SMILES | Cc1ccc(cc1N)C(O)=O | | CAS DataBase Reference | 2458-12-0(CAS DataBase Reference) | | NIST Chemistry Reference | 3-Amino-4-methylbenzoic acid(2458-12-0) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-24/25 | | WGK Germany | 3 | | HS Code | 29224995 | | Storage Class | 11 - Combustible Solids |
| | 3-Amino-4-methylbenzoic acid Usage And Synthesis |
| Uses | 3-Amino-4-methylbenzoic acid is used as a starting material to synthesize cyclopropamitosene compounds, which have potential antitumour activity. 3-Amino-4-methylbenzoic acid also has some partial herbicidal activity. | | Chemical Properties | white to light yellow crystal powder | | Uses | 3-Amino-4-methylbenzoic acid, is a raw material used in synthesis. It is also used as an organic intermediate, Pharmaceutical intermediate. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | 0.5 g of 3-nitro-4-methyl-benzoic acid (2.76 mmol, 1.0 eq.) was dissolved in 30 mL of methanol, 5% Pd/C was added and stirred vigorously for 3 hr. under hydrogen atmosphere. The catalyst was then filtered through a short silica gel column with ethyl acetate and the organic phase was concentrated in vacuum. 400 mg of 3-amino-4-methylbenzoic acid (2.65 mmol, 96%) was obtained as a pale yellow solid. |
| | 3-Amino-4-methylbenzoic acid Preparation Products And Raw materials |
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