Thalidomide-O-PEG4-azide manufacturers
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| | Thalidomide-O-PEG4-azide Basic information |
| Product Name: | Thalidomide-O-PEG4-azide | | Synonyms: | Thalidomide-O-PEG4-azide;4-((14-azido-3,6,9,12-tetraoxatetradecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;Thalidomide-O-PEG4-N3;1H-Isoindole-1,3(2H)-dione, 4-[(14-azido-3,6,9,12-tetraoxatetradec-1-yl)oxy]-2-(2,6-dioxo-3-piperidinyl)-;4-[(14-Azido-3,6,9,12-tetraoxatetradec-1-yl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione | | CAS: | 2380318-57-8 | | MF: | C23H29N5O9 | | MW: | 519.51 | | EINECS: | | | Product Categories: | peg;PROTACs-Please select | | Mol File: | 2380318-57-8.mol |  |
| | Thalidomide-O-PEG4-azide Chemical Properties |
| storage temp. | -20°C, sealed storage, away from moisture | | solubility | Soluble in Water, DMF, DCM, DMSO | | form | Oil | | color | Colorless to light yellow |
| | Thalidomide-O-PEG4-azide Usage And Synthesis |
| Description | Thalidomide-O-PEG4-Azide is a PROTAC linker that is reactive with alkyne or DBCO, BCN attached molecule via click chemistry | | Uses | Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | Cereblon | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Thalidomide-O-PEG4-azide Preparation Products And Raw materials |
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